Registration Dossier

Administrative data

Endpoint:
Henry's law constant
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: QSAR. Since dilactide undergoes immediate hydrolysis in contact with water, forming lactic acid, this is the moiety of interest by read-across.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Principles of method if other than guideline:
QSAR: ratio of solubility and vapour pressure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Henry's Law constant H
H:
0 atm m³/mol

Any other information on results incl. tables

1.13e-7 atm m3 mol-1

Applicant's summary and conclusion

Conclusions:
Lactic acid (as the relevant breakdown product of LL-lactide) will not volatilize from water.
Executive summary:

The Henry's law constant of lactic acid (as the relevant breakdown product of LL-lactide) was estimated with EPISuite, as the quotient of its vapour pressure and its aqueous solubility. Since lactic acid is miscible with water, this is in fact an overestimation of its propensity to evaporate from water.