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Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
For QMRF and QPRF please see the attached documents below.
Qualifier:
according to guideline
Guideline:
other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals, May 2008.
Principles of method if other than guideline:
(Q)SAR calculation
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): LL-lactide
- SMILES: CC1C(=O)OC(C(=O)O1)C (canonical); C[C@H]1C(=O)O[C@H](C(=O)O1)C (isomeric)
Key result
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Value:
1.027
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Details on results:
Biowin1 (Linear Biodeg Probability) 1.0273
Biowin2 (Non-Linear Biodeg Probability) 0.9999
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast

Biowin3 (Survey Model - Ultimate Biodeg) 3.1611
Biowin4 (Survey Model - Primary Biodeg) 4.0977
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer

Biowin5 (MITI Linear Biodeg Probability) 0.9965
Biowin6 (MITI Non-Linear Biodeg Probability) 0.9542
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable

Biowin7 (Anaerobic Linear Biodeg Prob) 1.0995
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast

The prediction is not dependent on stereochemistry.
Validity criteria fulfilled:
not applicable
Interpretation of results:
readily biodegradable
Conclusions:
LL-lactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.
Executive summary:

LL-lactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.

Description of key information

LL-lactide is considered to be readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

LL-lactide is predicted to be readily biodegradable by the validated QSAR model BIOWIN v4.10.