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Diss Factsheets
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EC number: 904-153-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A 96 hour acute semi-static toxicity study in zebra fish (Brachydanio rerio) was performed to assess the toxicity of Polyol TD. The study was performed according to GLP and the OECD 203 Test Guideline. The 96 hour LC50 was calculated to be 1250 mg/L (based nominal exposure concentrations), the corresponding NOEC was 500 mg/L (nominal concentration) (Olsson, 2008).
A static 48 hour definitive test was performed exposing Daphnia magna to a range of concentrations (125 - 4000 mg/L) of Polyol TD. The study was performed in accordance with the OECD guideline 202 and according to GLP. The 48 hour EC50 was calculated to be 1090 mg/L (based on nominal concentrations), the corresponding no-observed effect concentration was observed to be 500 mg/L (nominal concentration) ( Sjölin, 2008).
A 72 hour algal growth inhibition study, test species Pseudokirchneriella subcaptitata, was performed to determine the toxic effects of the test substance Polyol TD. The test was conducted according to OECD test guideline 201, and performed to GLP. Based on nominal exposure concentrations the 72 hour ErC50 was calculated to be 743 mg/L and the corresponding no-observed effect concentration (NOEC) was 62 mg/L. The 72 hour EyC50 was calculated to be 144 mg/L and the corresponding NOEC was 62 mg/L ( Sjölin, 2008).
The chronic toxicity of Polyol TD was tested in a preliminary 21-days Daphnia magna repoduction test according to OECD test guideline 211. The study was performed as a limit test using a single test concentration of 62 mg/L based on data of acute toxicity studies as mentioned above. The study demonstrates that there is no statistically significant effect at the limit concentration.Thus, D. magna is not more sensitive to Polyol TD than Pseudokirchneriella subcaptitata.
The toxicity of Polyol TD to activated sewage sludge was investigated in a respiration inhibition test according to OECD test guideline 209. Following three hours exposure to Polyol TD the EC50 was observed to be > 1000 mg/L (based on nominal exposure concentrations), the corresponding NOEC was observed to 1000 mg/L (Knight, polyol TD, 2010).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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