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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The systemic actions of thioglycerol with special reference to goitrogenic activity
Author:
Kensler, C.J. and Elsner, R.W.
Year:
1949
Bibliographic source:
J. Pharmacol. Exp. Therap., 97, 349-357.

Materials and methods

Principles of method if other than guideline:
other: systemic effects after i.p. application in mice
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Thioglycolic acid administered as ammonium salt
- Concentration: 10.7%
- Analytical purity: no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
27 (total number)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
200 mg/kg bw

Applicant's summary and conclusion

Conclusions:
Thioglycolate poisoning is characterized by a prolonged period of depression. Animals given fatal doses usually died between 12 and 36 hours after injection.