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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Study performed with cold wave product of unknown composition

Data source

Reference Type:
Thioglycolate cold wave process
McNally WD and Scull RH
Bibliographic source:
Arch. Dermatol. Syph. 57, 275-8

Materials and methods

Type of study / information:
Repeated skin irritation and toxicity
Principles of method if other than guideline:
Sub-acute (28 days) dermal toxicity and skin irritation test in guinea pigs.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium mercaptoacetate
EC Number:
EC Name:
Ammonium mercaptoacetate
Cas Number:
Molecular formula:
ammonium sulfanylacetate
Details on test material:
- Name of test material (as cited in study report): 6.5 % ammonium thioglycolate solution
- Analytical purity: no data

Results and discussion

Any other information on results incl. tables

During the experiment, twenty-eight applications were made, and at the end of the period no irritation of the skin was noted, and no depilatory action resulted. The skin and the hair of the animals remained healthy in appearance.


The examination of the blood of these animals revealed that the red cell count, the amount of haemoglobin in g/100cm³ of blood, the white cell count and the differential count were unaltered during the period of applications and two weeks after cessation of the experiment, indicating that absorption was never sufficient to cause a toxic reaction in the haemopoietic system.

Applicant's summary and conclusion