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Long-term toxicity to fish

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Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C10 -C12, isoalkanes, <2% aromatics estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is mg/l based on growth.
Validity criteria fulfilled:
yes
Conclusions:
The hydrocarbons, C13-C16, isoalkanes, cyclics, <2% aromatics, estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/l based on growth.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The hydrocarbons, C13-C16, isoalkanes, cyclics, <2% aromatics, estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/l based on growth.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information       

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

 

Description of key information

The aquatic toxicity toward fish under chronic conditions was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The hydrocarbons, C13-C16, isoalkanes, cyclics, <2% aromatics, estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/L, based on growth.

 

The 28-day NOELR for Hydrocarbons, C13-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C17, n-alkanes, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C20 (even numbered), n-alkanes, isoalkanes, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C20, n-alkanes, <2% aromatics inOncorhynchus mykissis >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Icosane in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Isohexadecane in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

Very long term exposure (31 weeks) to 1% n-alkanes in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Very long term exposure (45 weeks) to 1% pristane in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Very long term exposure (41 weeks) to 1% dodecylcyclohexane in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Key value for chemical safety assessment

Additional information

The aquatic toxicity toward fish under chronic conditions was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.