Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Calculation with ECOSAR v1.00 (EPIWIN software by US-EPA), Chronic Value for fish: 0.000365 mg/L

Key value for chemical safety assessment

Additional information

The prediction for long-term toxicity for aquatic organisms of the substance 2,4,6 -triisopropyl-m-phenylene diisocyanate was determined by the computer program ECOSAR v1.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2011). The program uses an extensive set of structure-activity relationships (SARs) to estimate the toxicity of chemicals discharged to water. For fish a Chronic Value (ChV) of 0.000365 mg/L was predicted. No GLP criteria are applicable for the usage of this tool, but due to the fact that it is a scientifically accepted calculation method the estimations performed are reliable with restrictions and can be used for the chemical safety assessment.