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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Jul 1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Scientifically sound study design; summary report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
1 h exposure period
GLP compliance:
no
Remarks:
performed before GLP
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Butyl acid phosphate
IUPAC Name:
Butyl acid phosphate
Test material form:
liquid: viscous
Details on test material:
clear thick liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
between 200 and 300 g initial body weight

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
The test material was metered, using a syringe infusion pump, into an air atomizing nozzle friven by houseline air. The resulting aerosol passed into a 40-liter exposure chamber containing 10 laboratory rats.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
20.28 mg/L (20280 mg/m3)
No. of animals per sex per dose:
10/dose
Control animals:
no
Details on study design:
no data
Statistics:
none

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
20.28 mg/L air (nominal)
Exp. duration:
1 h
Mortality:
no mortality reported
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
1 h exposure of rats to a Phosphoric acid, butyl ester aerosol resulted in no mortality. Therefore, the LC0 (1 h exposure) of Phosphoric acid, butyl ester aerosol was 20.28 mg/L (corresponding to a calculated LC0 (4 h exposure) of 5.07 mg/L).
Executive summary:

The test item was tested for its acute inhalation toxicity potential. 10 rats were exposed to an aerosol containing 20.28 mg/mL Phosphoric acid, butyl ester for 1h.

No mortality occurred. Based on the result of this study the test substance is not subject for labelling and classification requirements according to regulatory requirements.