Registration Dossier

Administrative data

Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material : α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene- 1-methanol
- Molecular formula : C33H33N3O
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
other: Rattus norvegicus
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Duration of test:
28-54 days

Results and discussion

Results (fetuses)

Effect levels (fetuses)

Dose descriptor:
LOEL
Effect level:
327.901 other: mg/kg/day
Based on:
test mat.
Basis for effect level:
other: fetotoxicity

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(C(O)(c2c3c(c(Nc4ccccc4)cc2)cccc3)c2ccc(N(C)C)cc2)ccc(N(C)C)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 7.1

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 7.56

Applicant's summary and conclusion

Conclusions:
The Low observed Effect Level (LOEL) value of α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol in Rattus norvegicus was observed to be 327.9008 mg/kg/day
Executive summary:
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The Low observed Effect Level (LOEL) value of α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol in Rattus norvegicus was observed to be 327.9008 mg/kg/day