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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1955

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 24 hrs. covered contact
Principles of method if other than guideline:
A group of four male albino New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg were immobilized during the 24-hour skin contact period with 20 ml/kg bw EP-302. The material remained in place during the 24-hour contact period with "Vinylite" sheeting. After the 24-hour period the sheeting was removed and the animals were caged for the remainder of the 14-day observation period. Thompson's method for calculating the LD50 was used.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Soybean oil, epoxidized
EC Number:
232-391-0
EC Name:
Soybean oil, epoxidized
Cas Number:
8013-07-8
IUPAC Name:
8013-07-8

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
other: 24 hours contact
Vehicle:
not specified
Duration of exposure:
24h
Doses:
20 ml/kg bw
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Mortality:
no
Clinical signs:
other: no

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A dosage of 20 ml/kg of the undiluted compound resulted in survival of all four rabbits. No particular damage other than transient erythema resulted.