Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

There are no reports on sensitisation caused by zinc tetraoxychromate, but zinc chromate-containing primers have been reported to cause allergic contact dermatitis in humans. Zinc chromates are currently classified as Skin Sens 1. Moreover, soluble chromates show positive results in several animal skin sensitisation tests.


Migrated from Short description of key information:
There are no reports on sensitisation caused by zinc tetraoxychromate, but zinc chromate-containing primers have been reported to cause allergic contact dermatitis in humans. Zinc chromates are currently classified as Skin Sens 1.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Zinc tetraoxychromate has not been reported to cause respiratory sensitisation. Data on respiratory sensitisation caused by zinc chromate is limited to a few old case reports, and compared to the amount of workers potentially exposed to various sparingly soluble chromates, the number of reported cases can be considered as very low. Other cases of occupational asthma have been reported among metalplating workers exposed to highly soluble chromium compounds. Some of these cases were evaluated and confirmed by bronchial challenge tests.

At the moment, there are no validated test methods for respiratory sensitisation

No sparingly soluble chromates have previously been classified as respiratory sensitizers, but highly soluble chromates are classified for respiratory sensitisation under EU.


Migrated from Short description of key information:
There are no data on respiratory sensitisation caused by zinc tetraoxychromate.

Justification for classification or non-classification

Zinc tetraoxychromate is suggested to be classified for skin sensitisation, based on the current classification and read-across from case reports on zinc chromate.

Due to the lack of data on respiratory sensititsation caused by zinc tetraoxychromate or other sparingly soluble chromates, and the lack of appropriate test methods, no classification is suggested for respiratory sensitisation.