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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across to strontium chromate. OECD Guideline study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): L203E Chromate de strontium
- Molecular formula (if other than submission substance): SrCrO4
- Molecular weight (if other than submission substance): 203,62
- Substance type: powder
- Physical state: solid
- Analytical purity: 95%
- Impurities (identity and concentrations): 2.6% BaCrO4
- Composition of test material, percentage of components: CrO3: 47.70%; Sro: 49.40%
- Purity test date: no data
- Lot/batch No.: 019031
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: room temperature, protected from humidity
- Other: pH in purified water 7-8

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: CEGAV, Saint Mars d'Egrenne, France
- Age at study initiation: no data
- Weight at study initiation: 2.3 ± 0.1 kg
- Housing: indicidually in polystyrene cages
- Diet (e.g. ad libitum): free access to 110 pelleted diet (UAR, Villemoisson, Epinay-sur-Orge, France)
- Water (e.g. ad libitum): Micropore filtered water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3 °C
- Humidity (%): 30-70%
- Air changes (per hr): 12 cycles/h, filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12 h

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg
Duration of treatment / exposure:
3 minutes on left flank and 4 hours on right flank.
Observation period:
1, 24, 48, 72 h after removal of the dressing. In absence of irritation, the study was ended on day 4.
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: semi-occlusive dressing

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no


SCORING SYSTEM:
erythema and eschar formation: scoring scale 0-4
oedema formation: scoring scale 0-4

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h, 48 h, 72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h, 48 h, 72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
No signs of irritation.
Other effects:
Yellow coloration of the skin.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Strontium is not irritating when applied topically on rabbits according to a standard test method.
Executive summary:

Skin irritation/corrosion of strontium chromate was tested on rabbits using a standard test protocol (OECD 404). The results showed no signs of irritation, and strontium chromate can therefore be classified as non-irritant.