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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Screening test for acute inhalation, with significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Study considered as a screening, meets generally accepted scientific standards, but limited technical standard. Exposure to an aerosol, the maximum possible that was technically achievable due to the physical properties of the test material.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol
Details on test material:
- Name of test material (as cited in study report): MIPB, isopropyl biphenyl
- Substance type: organic
- Physical state: liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
--

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
The animals were exposed for one hour to MIPB in a 38-liter glass inhalation chamber. The MIPB aerosol was generated into the chamber by
means of a glass nebulizer through which an airflow of 10 liters/minute was passed.

No rationale for the dosage is given.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
1 h
Concentrations:
1.67 mg/L, calculated as follows:
A total of 1001.6 mg of MIPB was generated into the exposure chamber during the one-hour period during which 600 liters of air was passed
through the chamber.
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC0
Effect level:
1.67 mg/L air
Based on:
test mat.
Remarks:
nominal concentration
Exp. duration:
1 h
Mortality:
no deaths
Clinical signs:
During the first minute of exposure, all rats exhibited compound awareness and slight hyperactivity. After five minutes and for the remainder of the exposure period, all rats were inactive. Several animals exhibited a slight discharge around the eyes. At the termination of exposure, one rat had a reddish discharge around the eyes.
All animals exhibited normal appearance and behavior throughout the 14-day post-exposure observation period.
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
other: not fully evaluable based on current standards
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
The inhalation exposure of 10 male albino rats to 1.67 mg/liter of MIPB would not appear to be toxic, since no rats died and no serious pharmacotoxic signs were observed.