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EC number: 633-172-6 | CAS number: 66415-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a local lymph node assay according to OECD 442B (BASF SE, 2013), three groups of five female mice each were treated once daily with the test item at concentrations of 1, 2, and 5% (w/w) in acetone:olive oil (4:1 v/v) by topical application to the dorsum of each ear for three consecutive days. Concentrations at and above 10% led to excessive irritation as determined by ear weight increase > 25% in the pretests performed. Four days after the first topical application the mice were intraperitoneally injected with BrdU. Approximately 24 hours after intraperitoneally injection, the mice were sacrificed and the draining auricular lymph nodes excised, pooled per animal and immediately weighed. Furthermore, after excision of the lymph nodes, both ears of the mice were punched at the apical area using a biopsy punch and were immediately weighed pooled per animal using an analytical balance. Afterwards, single cell suspensions of lymph node cells were prepared from lymph nodes pooled per animal. An aliquot of each cell suspension was used for determination of lymph node cell count. The proliferative capacity of pooled lymph node cells was determined by the incorporation of BrdU. The animals did not show any relevant signs of systemic toxicity. Very slight erytheme and incrustions were observed in the high dose group. Stimulation Indices (S.I.) of 1.7, and 2.4 were determined with the test item at concentrations of 1, 2 and 5% (w/w) , respectively. Due to the fact that no clear dose response was observed an EC1.6 could not be calculated.
A statistically significant and biologically relevant increase in BrdU labeling and lymph was observed for the low (1%) and high (5%) dose group. This was also observed for these dose groups in lymph node weights and lymph node cell count, thus corroborating the sensitizing potential. The cut-off-value for a positive response regarding the lymph node cell count index of 1.55 reported BALB/c mice was exceeded in the low and high dose group (index of 1.6 (1%) and 1.9 (5%).
Thus the test substance Aminopropyl Vinyl Ether is a skin sensitizer under the test conditions of this study.
Justification for classification or non-classification
Based on these results Aminopropyl Vinyl Ether required to be classified with R43 according to 67/548/EEC and as a skin sensitizer Cat.1 according to CLP/EU-GHS requirements.
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