2,2-di(tetrahydrofuryl)propane

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 March - 15 May, 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study has been performed according to OECD and/or EU guidelines and according to GLP principles.

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

The concentration of the test substance in the test samples was determined immediately after preparation (t=0), after 2.4 hours and after 5 days. The samples taken at t > 0 were cooled to room temperature using running tap water.

Buffers:

Acetate buffer pH 4: solution of 16.6% 0.05 M sodium acetate and 83.4% 0.05 M acetic acid.
Phosphate buffer pH 7: solution of 0.05 M potassium dihydrogenphosphate adjusted to pH 7 using 1 N sodium hydroxide.
Borate buffer pH 9: solution of 0.05 M boric acid and 0.05 M potassium chloride adjusted to pH 9 using 1 N sodium hydroxide.

Details on test conditions:

Test substance solutions were prepared in the buffer solutions at a nominal concentration between 662 - 748 mg/l. The solutions were filter-sterilised through a 0.2 µm membrane filter and transferred into sterile glass vessels. To exclude oxygen, nitrogen gas was purged through the solutions for 5 minutes. Each vessel was sealed and placed in a thermostatically controlled water bath at 50.0°C +/- 0.1°C.

Duration:

5 d

Temp.:

50 °C

Positive controls:

no

Negative controls:

yes

Remarks:

blank buffer solution

Preliminary study:

The result for the samples taken at t=0 hours and t=2.4 hours indicated that there was a spread on the results. Because neither improvement of the method nor development of a more accurate method is possible, it was decided to analyse t=5 days samples in triplicate.

Transformation products:

not measured

% Recovery:

97

pH:

4

Temp.:

50 °C

Duration:

5 d

% Recovery:

108

pH:

7

Temp.:

50 °C

Duration:

5 d

% Recovery:

94

pH:

9

Temp.:

50 °C

Duration:

5 d

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

Key result

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Details on results:

At pH 4, pH 7 and pH 9, a decrease in concentration < 10% was observed after 5 days. It demonstrates that the half-life time of the test substance at 25°C > 1 year which is as expected based on the chemical structure of the test substance. According to the guideline, no further tests were required.

Validity criteria fulfilled:

not applicable

Conclusions:

Ditetrahydrofurylpropane is hydrolytically stable.

Description of key information

A test was conducted according to EU method C.7. At pH 4, pH 7 and pH 9, a decrease in concentration < 10% was observed after 5 days. It demonstrates that the half-life time of the test substance at 25°C > 1 year which is as expected based on the chemical structure of the test substance.

Additional information

Ditetrahydrofurylpropane is hydrolytically stable at pH 4, 7 and 9. The half-life time at 25°C is > 1 year for pH 4, 7 and 9.