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EC number: 242-555-3 | CAS number: 18755-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A valid skin irritation/corrosion study according OECD 404 and a valid eye irritation study according OECD 405 are available.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 500 mg dimethyl propylphosphonate were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 14 according to DRAIZE.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 animals
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0 - 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: erythema was fully reversible in 2 of 3 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 0
- Remarks on result:
- other: No edema was seen at any animal at any time point (1h - 14d) after 4 h of exposure
- Other effects:
- no other effects found
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Dimethyl propylphosphonate (500 mg) was semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 4 hours. Evaluation of skin irritation was made until day 14 according to Draize.
Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).
Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively. Erythema score = 0.66, edema score = 0.
Therefore a classification is not justified.
Reference
Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).
Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to DRAIZE.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 3 animals
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1.55
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Other effects:
- no other effects
- Executive summary:
A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to Draize.
Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).
Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.
The findings indicates that dimethyl propylphosphonate may be considered as slight irritating to the eyes. According GHS a classification as Eye Irrit. 2; H 319 is appropritate due to a cornea score = 1.
Reference
Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).
Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the skin irritation/corrosion study dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).
Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively. Mean scores at 24, 48, and 73 hours: Erythema score = 0.66, edema score = 0.
In the eye irritation study dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).
Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days. Mean scores at 24, 48, and 72 hours: Cornea score = 1, iris score = 0.33, conjunctiva score = 1.55, chemosis score = 1.44)
Justification for selection of skin irritation / corrosion endpoint:
Only available study
Justification for selection of eye irritation endpoint:
Only available study
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
The findings indicates that dimethyl propylphosphonate may be considered as slight irritating to the eyes. According to GHS a classification as Eye Irrit. 2; H 319 is appropriate due to a mean cornea score = 1at 24, 48, and 72 hours.
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