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EC number: 209-667-4 | CAS number: 589-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitization:
3-octanol was used as test material to evaluate skin sensitization potential by human maximization test.
3-octanol 12% in petrolatum was applied on the skin of 29 human volunteers. No skin reactions were observed. Hence, 3-octanol can be considered as not skin sensitizer for human skin.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
- Qualifier:
- according to guideline
- Guideline:
- other: Maximization test
- Principles of method if other than guideline:
- To evaluate skin sensitization potential of 3-octanol on 29 human volunteers
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
- Justification for non-LLNA method:
- not specified
- Specific details on test material used for the study:
- Name of the test chemical: 3-Octanol
Molecular Formula: C8H18O
Molecular Weight: 130.229 g/mole
Substance type: organic
Physical state: Liquid - Species:
- other: humans
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data available
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 12% in petrolatum
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 12% in petrolatum
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 29 human volunteers
- Details on study design:
- no data available
- Challenge controls:
- no data available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 12% in petrolatum
- No. with + reactions:
- 0
- Total no. in group:
- 29
- Clinical observations:
- no dermal reactions observed
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- 3-octanol 12% in petrolatum when tested for skin sensitization on 29 human volunteers showed no skin reaction. Hence, 3-octanol can be considered as not skin sensitizer for human skin.
- Executive summary:
3-octanol was used as test material to evaluate skin sensitization potential by human maximization test.
3-octanol 12% in petrolatum was applied on the skin of 29 human volunteers. No skin reactions were observed. Hence, 3-octanol can be considered as not skin sensitizer for human skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitization:
Various studies have been investigated for assessing the dermal sensitization potential of 3-octanol to a greater or lesser extent. The studies are based on in vivo experiments in humans along with predicted data for target chemical and its structurally similar read across chemicals, 2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3].The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.
A maximization test was carried out (Food and Cosmetics Toxicology, Volume 17, Supplement, December 1979, Page 881) to assess the dermal sensitization potential of 3-octanol in humans. 3-octanol 12% in petrolatum was applied on the skin of 29 human volunteers. No skin reactions were observed. Hence, 3-octanol can be considered as not skin sensitizer for human skin.
The skin sensitization potential of Octan-3-ol was estimated by SSS (2018) using OECD QSAR toolbox v3.3 with log kow as the primary descriptor. Octan-3-ol was predicted to be not sensitizing to the skin of male/female Hartley guinea pigs.
Skin sensitization effects were also estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database for 3 -octanol. Based on estimation, no skin sensitization reactions were observed in guinea pigs and humans. Therefore, 3 -octanol was considered to be not sensitizing.
The experimental and estimated results are in agreement with each other indicating a strong possibility of 3-octanol being not sensitizing to skin.
These results are supported by the experimental study summarized in Food and Chemical Toxicology, 48, (2010), S1–S46; for the structurally similar read across chemical,2 -ethylhexyl alcohol[CAS: 104-76-7]. 2-ethylhexyl alcohol[CAS: 104-76-7] 4% in petrolatum was applied on the skin of 29 human volunteers.
No skin reactions were observed. Hence, 2-ethylhexyl alcohol[CAS: 104-76-7] can be considered as not skin sensitizer for human skin.
The above results are further supported by the experimental study summarized in Food and Cosmetics Toxicology, Volume 13, Issue 6, 1975, Pages 695-696; for the structurally similar read across chemical; Hexan-1-ol[CAS: 111-27-3]. Hexan-1-ol 1% in petrolatum was applied on the skin of 21 human volunteers.
No skin reactions were observed. Hence, hexan-1-ol can be considered as not skin sensitizer for human skin.
Based on the available data for the target as well as read across chemicals and applying the weight of evidence approach,3-octanol was not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Available data for 3-Octanol indicates that it is not likely to cause any dermal sensitization to skin.
3 -Octanol can be considered to be not sensitizer to skin and can be classified under the category “Not Classified” as per CLP regulation.
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