Registration Dossier
Registration Dossier
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EC number: 200-902-6 | CAS number: 75-79-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data on the reproductive toxicity of trichloro(methyl)silane are available, therefore data on methyltrimethoxysilane have been read-across. Since the read-across substance is not corrosive, it should be assumed that additional local effects, probably of a corrosive nature, and secondary systemic effects, will be observed with trichloro(methyl)silane.
Short description of key information:
No data on the reproductive toxicity of trichloro(methyl)silane are available, therefore data on methyltrimethoxysilane (MTMS) have been read-across. The basis for this read-across is that trichloro(methyl)silane and methyltrimethoxysilane are both rapidly hydrolysed to methylsilanetriol. Exposure to methyltrimethoxysilane was not associated with reproductive toxicity. The findings support a NOAEL of at least 1000 mg/kg bw/day. However, since trichloro(methyl)silane is corrosive, additional local effects can be expected for this substance.
Effects on developmental toxicity
Description of key information
No data on the developmental toxicity of trichloro(methyl)silane are available, therefore data on methyltrimethoxysilane have been read-across. The basis for this read-across is that trichloro(methyl)silane and methyltrimethoxysilane are both rapidly hydrolysed to methylsilanetriol. Exposure to methyltrimethoxysilane was not associated with reproductive toxicity. The findings support a NOAEL of at least 1000 mg/kg bw/day. However, since trichloro(methyl)silane is corrosive, additional local effects can be expected for this substance.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
No data on the reproductive toxicity of trichloro(methyl)silane are available, therefore data on methyltrimethoxysilane have been read-across. Since the read-across substance is not corrosive, it should be assumed that additional local effects, probably of a corrosive nature, and secondary systemic effects, will be observed with trichloro(methyl)silane.
Justification for classification or non-classification
The available read-across data do not suggest that trichloro(methyl)silane should be classified for reproductive and developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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