Registration Dossier
Registration Dossier
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EC number: 200-143-0 | CAS number: 52-51-7
Endpoint summary
Administrative data
Description of key information
Stability
Bronopol is slowly degraded in air by photochemical processes (half-life = 12.106 d). In water, bronopol is photodegraded at environmentally relevant temperatures with a half-life of 24.3 h. In water, the hydrolysis is strongly pH dependent. Bronopol hydrolyses slowly under acidic conditions (pH 4) with a DT50 of 120 hours (25°C). At neutral and alkaline conditions (pH 7 - pH 9), the half-life decreases to a DT50 of 2.4 hours (25°C).
Biodegradation
Bronopol is considered to be not readily biodegradable according to OECD criteria. Mineralization of 20 % was observed after 28 days in the key study. Nevertheless, in a simulation study, a half-life of DT50 8.3 min at 19.8 °C was observed. In other words, even though bronopol has to be regarded as "not readily biodegradable", a total degradation of 97.53% will be achieved in the STP according to simple treat 4.0.
Bioaccumulation
Accumulation in organisms is not to be expected. The measured log Pow at pH 7 is determined to be 0.22 and therefore far below the threshold value of log Pow >= 3. The waiving criterion is well met. The conclusion is further strengthened by the results of a QSAR calculation which showed a BCF of 3.16. Same applies for relavant metabolites with BCF values ranging from 2.9 - 3.9 L/kg wwt according to CATALOGIC v5.15.2.14 (BCF base-line model v05.12).
Transport and distribution
Adsorption of bronopol to solid soil phase is not expected. Based on calculations it can be expected that the substance will not evaporate from the water surface to the atmosphere. According to Mackay Level 1, 99.97 % of bronopol will be distributed to the water phase.
Additional information
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