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Annex III inventory

Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

γ-HCH or γ-BHC

EC / List no.: 200-401-2 CAS no.: 58-89-9
Information source
# Harmonised classification for acute toxicity: The substance is listed in Annex VI of CLP as: Acute Tox. 3; The substance is listed in Annex VI of CLP as: Acute Tox. 4 # Harmonised classification for aquatic toxicity: The substance is listed in Annex VI of CLP as: Aquatic Acute 1; The substance is listed in Annex VI of CLP as: Aquatic Chronic 1 # Harmonised classification for effects on or via lactation: The substance is listed in Annex VI of CLP as: Effects on or via lactation # Harmonised classification for specific target organ toxicity: The substance is listed in Annex VI of CLP as: STOT RE 2 # Suspected bioaccumulative: Bioaccumulation Canada database in the Toolbox reports at least one value above the B threshold of 2,000 L/Kg (3.3 log units) # Suspected carcinogen: The Toolbox profiler 'Carcinogenicity (genotox and nongenotox) alerts by ISS' gives an alert for carcinogenicity; CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (EXPERIMENTAL value); IARC monographs classified the substance as carcinogenic or probably/possibly carcinogenic; carcinogen according to ISSCAN; reasonably anticipated to be a human carcinogen according to NTP 13th RoC # Suspected hazardous to the aquatic environment: EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 1.79 mg/L (EXPERIMENTAL value); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 0.0713 mg/L (EXPERIMENTAL value); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is 'Toxic-3 (between 10 and 100 mg/l) (good reliability)'; Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 18.34 mg/L (good reliability);The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 2.24 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of 1.57 mg/L; The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 2.76 mg/L # Suspected mutagen: SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is NON-Mutagen (EXPERIMENTAL value); equivocal mutagenicity data according to ISSSTY # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is NON Readily Biodegradable (moderate reliability); Soil OASIS database in the Toolbox contains at least one experimental data from biodegradation in soil test reporting a value equal or greater than 120 days;The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin irritant: The Danish QSAR database contains information indicating that the substance is predicted as skin irritant # Suspected toxic for reproduction: The Toolbox profiler 'DART scheme v.1.0' gives an alert for toxicity to reproduction;Developmental/Reproductive Toxicity library (PG) in VEGA (Q)SAR platform predicts that the chemical is Toxicant (moderate reliability)

Download the full Annex III Inventory

You can download the full Annex III inventory as XLS format.

Download Annex III Inventory

 

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