Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry.

Filter the list

Substance Identifier

Reason for inclusion:

Date of inclusion:

Showing 1 - 50 of 240 results.

Substance name	EC No.	CAS No.	Date of inclusion	Reason for inclusion	Decision
(±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one covering any of the individual isomers and/or combinations thereof (4-MBC) show/hide (±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one EC No.: 253-242-6 \| CAS No.: 36861-47-9 (3E)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 1782069-81-1 (1R,3E,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 95342-41-9 (1S,3E,4R)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-30-1 (1R,3Z,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-21-0 (1R,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 741687-98-9 (1S,3Z,4R)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-25-4	-	-	17-Jan-2022	Endocrine disrupting properties (Article 57(f) - human health)	D(2021)10043-DC	Details
1, 2-dimethoxyethane; ethylene glycol dimethyl ether (EGDME)	203-794-9	110-71-4	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
1,1'-[ethane-1,2-diylbisoxy]bis[2,4,6-tribromobenzene]	253-692-3	37853-59-1	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
1,2,3-trichloropropane	202-486-1	96-18-4	20-Jun-2011	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/31/2011	Details
1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters or mixed decyl and hexyl and octyl diesters with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5) show/hide 1,2-Benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters EC No.: 272-013-1 \| CAS No.: 68648-93-1 1,2-Benzenedicarboxylic acid, di-C6-10-alkyl esters EC No.: 271-094-0 \| CAS No.: 68515-51-5	-	-	15-Jun-2015	Toxic for reproduction (Article 57c)	ED/39/2015	Details
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich	276-158-1	71888-89-6	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters	271-084-6	68515-42-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear	271-093-5	68515-50-4	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear	284-032-2	84777-06-0	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1,2-bis(2-methoxyethoxy)ethane (TEGDME; triglyme)	203-977-3	112-49-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
1,2-dichloroethane	203-458-1	107-06-2	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
1,2-diethoxyethane	211-076-1	629-14-1	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC)	219-514-3	2451-62-9	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) -	423-400-0	59653-74-6	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
1,3-propanesultone	214-317-9	1120-71-4	17-Dec-2015	Carcinogenic (Article 57a)	ED/79/2015	Details
1,4-dioxane	204-661-8	123-91-1	08-Jul-2021	Carcinogenic (Article 57a) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2021)4569-DC	Details
1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene (“Dechlorane Plus”™) covering any of its individual anti- and syn-isomers or any combination thereof show/hide (1S,2S,5R,6R,9S,10S,13R,14R)-1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.1⁶,⁹.0²,¹³.0⁵,¹⁰]octadeca-7,15-diene EC No.: - \| CAS No.: 135821-03-3 (1S,2S,5S,6S,9R,10R,13R,14R)-1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.1⁶,⁹.0²,¹³.0⁵,¹⁰]octadeca-7,15-diene EC No.: - \| CAS No.: 135821-74-8 1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene EC No.: 236-948-9 \| CAS No.: 13560-89-9 rel-(1R,4S,4aS,6aS,7S,10R,10aR,12aR)-1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e]cyclooctene EC No.: - \| CAS No.: - rel-(1R,4S,4aS,6aR,7R,10S,10aS,12aR)-1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e]cyclooctene EC No.: - \| CAS No.: -	-	-	15-Jan-2018	vPvB (Article 57e)	ED/01/2018	Details
1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one 3-benzylidene camphor; 3-BC	239-139-9	15087-24-8	15-Jan-2019	Endocrine disrupting properties (Article 57(f) - environment)	ED/88/2018 EU/2018/2013	Details
1-bromopropane (n-propyl bromide)	203-445-0	106-94-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1-Methyl-2-pyrrolidone (NMP)	212-828-1	872-50-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1-vinylimidazole	214-012-0	1072-63-5	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol	201-236-9	79-94-7	17-Jan-2023	Carcinogenic (Article 57a)	D(2022)9120-DC	Details
2,2'-dichloro-4,4'-methylenedianiline	202-918-9	101-14-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
2,2-bis(4'-hydroxyphenyl)-4-methylpentane AP-5	401-720-1	6807-17-6	15-Jan-2019	Toxic for reproduction (Article 57c)	ED/88/2018	Details
2,2-bis(bromomethyl)propane-1,3-diol (BMP); 2,2-dimethylpropan-1-ol, tribromo derivative/3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA); 2,3-dibromo-1-propanol (2,3-DBPA) show/hide 2,2-bis(bromomethyl)propane-1,3-diol (BMP) EC No.: 221-967-7 \| CAS No.: 3296-90-0 2,2-dimethylpropan-1-ol, tribromo derivative (TBNPA) EC No.: 253-057-0 \| CAS No.: 36483-57-5 3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA) EC No.: - \| CAS No.: 1522-92-5 2,3-dibromo-1-propanol (2,3-DBPA) EC No.: 202-480-9 \| CAS No.: 96-13-9	-	-	08-Jul-2021	Carcinogenic (Article 57a)	D(2021)4569-DC	Details
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts and its acyl halides covering any of their individual isomers and combinations thereof show/hide ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate EC No.: - \| CAS No.: 62037-80-3 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionyl fluoride EC No.: 218-173-8 \| CAS No.: 2062-98-8 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid EC No.: 236-236-8 \| CAS No.: 13252-13-6 potassium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionate EC No.: 266-578-3 \| CAS No.: 67118-55-2 Propanoic acid, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-, (+)- EC No.: - \| CAS No.: 75579-39-4 Propanoic acid, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-, (-)- EC No.: - \| CAS No.: 75579-40-7	-	-	16-Jul-2019	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	ED/71/2019	Details
2,4,6-tri-tert-butylphenol	211-989-5	732-26-3	23-Jan-2024	Toxic for reproduction (Article 57c) PBT (Article 57d)	D(2023)8585-DC	Details
2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327)	223-383-8	3864-99-1	17-Dec-2015	vPvB (Article 57e)	ED/79/2015	Details
2,4-dinitrotoluene	204-450-0	121-14-2	13-Jan-2010	Carcinogenic (Article 57a)	ED/68/2009	Details
2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)	247-384-8	25973-55-1	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol (UV-329)	221-573-5	3147-75-9	23-Jan-2024	vPvB (Article 57e)	D(2023)8585-DC	Details
2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350)	253-037-1	36437-37-3	17-Dec-2015	vPvB (Article 57e)	ED/79/2015	Details
2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers show/hide 2-(4-tert-butylbenzyl)propionaldehyde EC No.: 201-289-8 \| CAS No.: 80-54-6 (2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-30-2 (2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-31-3	-	-	08-Jul-2021	Toxic for reproduction (Article 57c)	D(2021)4569-DC.pdf	Details
2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one	438-340-0	119344-86-4	23-Jan-2024	Toxic for reproduction (Article 57c)	D(2023)8585-DC	Details
2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320)	223-346-6	3846-71-7	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone CG 25-369; IRGACURE 369; TK 11-319	404-360-3	119313-12-1	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
2-ethoxyethanol	203-804-1	110-80-5	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details
2-ethoxyethyl acetate	203-839-2	111-15-9	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (DOTE)	239-622-4	15571-58-1	17-Dec-2014	Toxic for reproduction (Article 57c)	ED/108/2014	Details
2-Methoxyaniline, o-Anisidine	201-963-1	90-04-0	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
2-methoxyethanol	203-713-7	109-86-4	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details
2-methoxyethyl acetate	203-772-9	110-49-6	16-Jul-2019	Toxic for reproduction (Article 57c)	ED/71/2019	Details
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97	400-600-6	71868-10-5	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
2-methylimidazole	211-765-7	693-98-1	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine ZOLDINE MS-PLUS	421-150-7	143860-04-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
4,4'- Diaminodiphenylmethane (MDA)	202-974-4	101-77-9	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
4,4'-(1-methylpropylidene)bisphenol	201-025-1	77-40-7	08-Jul-2021	Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	209-218-2	561-41-1	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
4,4'-bis(dimethylamino)benzophenone (Michler’s ketone)	202-027-5	90-94-8	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
4,4'-isopropylidenediphenol Bisphenol A; BPA	201-245-8	80-05-7	12-Jan-2017	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	ED/30/2017 ED/01/2017 ED 01/2018	Details

Showing 1 - 50 of 240 results.

Export search results to:

Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Further information

See a problem or have feedback?

Footer Nav Items