Registration Dossier
Registration Dossier
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EC number: 439-210-6 | CAS number: 554-62-1
Endpoint summary
Administrative data
Description of key information
Invertebrates: 48h-EC50 (Daphnia magna, immobility) = 131 µg/L (mean measured)
Algae: 72h-ErC50 (Pseudokirchneriella subcapitata, growth rate) = 166 µg/L; 72h-ErC10 (Pseudokirchneriella subcapitata, growth rate) = 45.5 µg/L (mean measured)
Additional information
Acute aquatic toxicity
Reliable key studies are available for aquatic algae (according to OECD 201, GLP) and invertebrates (according to OECD 202, GLP). Adverse effects of the submission substance were observed in both species, algae and invertebrates. The validity criteria of the guidelines are fulfilled and results considered reliable and adequate for the aquatic hazard assessment.
Inhibition of growth (r) and inhibition of yield (b) of aquatic algae were observed in a dose-response relationship during the 72 hours exposure period. No adverse effects were observed in the two lowest test concentration, i.e. 8.27 and 12.7 µg/L. Derived effect concentrations on growth inhibition were: 72h-ErC50 = 166 µg/L, 72h-ErC10 = 45.5 µg/L, and 72h-NOErC = 12.7 µg/L (based on geom. measured concentrations). The derived effect concentrations on yield of biomass were: 72h-EbC50 = 50.1 µg/L, 72h-EbC10 = 18.8 µg/L, and 72h-NOEbC = 12.7 µg/L (based on geom. measured concentrations). Microscopic evaluation of the cells at the start and end of exposure revealed no morphological abnormalities.
Immobilisation of Daphnia magna was observed in a dose-response relationship during the 48 hours exposure period. The derived effect concentrations were: 48h-EC50 = 0.131 mg/L (95 % confidence limits: 0.106 - 0.161 mg/L).
In conclusion, the most sensitive species concerning short-term toxicity is Daphnia magna.
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