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EC number: 224-662-7 | CAS number: 4441-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Jan - 28 May 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- 17 Jul 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Trimorpholinophosphine oxide
- EC Number:
- 224-662-7
- EC Name:
- Trimorpholinophosphine oxide
- Cas Number:
- 4441-12-7
- Molecular formula:
- C12H24N3O4P
- IUPAC Name:
- trimorpholinophosphine oxide
- Test material form:
- solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: mixed microbial population (activated sewage sludge), effluent of municipal sewage treatment plant of the city of Darmstadt (Südhessische Gas und Wasser AG)
- Treatment: Filtration through a coarse folded filter
- Concentration in the reaction mixture: 5 mL/L
- Preparation/Conditioning: Aeration for 5 days - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 1 000 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 ± 2 °C
TEST SYSTEM
- The test material was dissolved in a mineral medium and inoculated with a mixed microbial population, and incubated under arrobic conditions in the dark for 28 days. During the incubation period, biodegradation of the test material was determined by the decrease in the concentration of dissolved oxygen in the test material preparation.
SAMPLING
- Sampling frequency: Sampling was performed on Days 0, 7, 14, 21, and 28
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- Toxicity control: 20.1% degradation after 28 d.
BOD5 / COD results
- Results with reference substance:
- Degradation of reference item (Aniline) after 28 d: 78%.
Any other information on results incl. tables
Tab 1: Degradation [%] of test item, reference and toxicity control
Time [d] |
% degradation |
||
Test material |
Aniline |
Toxicity Control |
|
7 |
4 |
75 |
38 |
14 |
4 |
83 |
43 |
21 |
5 |
70 |
30 |
28 |
3 |
78 |
33 |
The degradation of the reference compound Aniline reached 60% by Day 14, confirming the activity of the inoculum.
The criterion for ready biodegradability of > 60% removal of the ThOD within the 28 d period was not reached. Therefore, the test substance cannot be considered as readily biodegradable.
The degradation of the toxicity control was > 25% (ThOD) and > 35% (DOC) (required pass level) after 14 d.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item is not readily biodegradable according to the criteria of the OECD guideline 301 D.
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