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Diss Factsheets
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EC number: 207-892-2 | CAS number: 499-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals
- Author:
- D.R. Schoneker , C.C. DeMerlis, J.F. Borzelleca
- Year:
- 2 003
- Bibliographic source:
- Food and Chemical Toxicology 41 (2003) 405–413
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Phthalic acid in mice
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- Phthalic acid
- EC Number:
- 201-873-2
- EC Name:
- Phthalic acid
- Cas Number:
- 88-99-3
- Molecular formula:
- C8H6O4
- IUPAC Name:
- Phthalic acid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phthalic acid
- Molecular formula (if other than submission substance): C8H6O4
- Molecular weight (if other than submission substance): 166.131 g/mole
- Substance type: Organic
Test animals
- Species:
- mouse
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Canadian Breeding Laboratories
- Age at study initiation: No data available
- Weight at study initiation: 18–20 g,
- Fasting period before study: Animals were fasted for a period of 4–16 h prior to treatment.
- Housing: No data available
- Diet (e.g. ad libitum): Purina Rodent Chow food, ad libitum
- Water (e.g. ad libitum): water, ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 5% gum acacia
- Details on oral exposure:
- EHICLE
- Concentration in vehicle: 5000 mg/kg bw
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: 5% gum acacia
- Lot/batch no. (if required): No data available
- Purity: No data available
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): Phthalic acid was suspended in 5% gum acacia.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 male , 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: over the 24-h to 14 day.
- Frequency of observations and weighing: over the 24-h period
- Necropsy of survivors performed: Yes
- Other examinations performed: Mortality, clinical signs and gross pathology were observed - Statistics:
- LD50 values were calculated from the mortality data (Litchfield and Wilcoxan, 1949).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated mice at 5000 mg/kg bw
- Clinical signs:
- CNS depression was observed in treated mice.
- Body weight:
- No data available
- Gross pathology:
- Inflammation of the gastrointestinal tract was observed in treated mice.
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified
- Conclusions:
- LD50 was considered to >5000 mg/kg bw when Albino male and female mice were treated with Phthalic acid orally by gavage.
- Executive summary:
In a acute oral toxicity study,Albinomale and female micewere treated withPhthalic acid in the concentration of 5000 mg/kg bw orally by gavage in 5% gum acacia. No mortality was observed in treated mice at 5000 mg/kg bw.CNS depression and Inflammation of the gastrointestinal tract was observed in treated mice. Therefore,LD50 was considered to >5000 mg/kg bw whenAlbino male and female micewere treated withPhthalic acid orally by gavage.
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