Registration Dossier
Registration Dossier
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EC number: 215-147-8 | CAS number: 1306-23-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restriction. Not according to GLP nor to specific test guidelines.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Chromosomal aberrations in cultured human leucocytes induced by cadmium sulfide
- Author:
- Shiraishi Y, Kurahashi H and Yoshida TW
- Year:
- 1 972
- Bibliographic source:
- Proc Jap Acad 48(2): 133-137
Materials and methods
- Principles of method if other than guideline:
- CA:
-incubation time: 72 hours
-number of cells observed: 50 metaphases per culture
-staining: Giemsa - GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Cadmium sulphide
- EC Number:
- 215-147-8
- EC Name:
- Cadmium sulphide
- Cas Number:
- 1306-23-6
- Molecular formula:
- CdS
- IUPAC Name:
- cadmium(2+) sulfanediide
- Details on test material:
- name of test substance: cadmium sulphide
Constituent 1
Method
- Target gene:
- not applicable
Species / strain
- Species / strain / cell type:
- lymphocytes:
- Details on mammalian cell type (if applicable):
- not applicable
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- not applicable
- Metabolic activation system:
- not applicable
- Test concentrations with justification for top dose:
- 6.2x10-2 µg/ml
- Vehicle / solvent:
- no information
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- no
- Positive control substance:
- no
- Remarks:
- none
- Details on test system and experimental conditions:
- none
- Evaluation criteria:
- no information
- Statistics:
- not reported
Results and discussion
Test results
- Species / strain:
- lymphocytes:
- Metabolic activation:
- not applicable
- Genotoxicity:
- positive
- Remarks:
- CA
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not specified
- Additional information on results:
- none
- Remarks on result:
- other: strain/cell type: human leucocytes
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
| duration of treatment (hours) | total No of cells observed | No of cells with chromatid breaks (%) | No of cells with isochromatid breaks (%) | No of cells with translocation (%) | No of cells with dicentric chromosomes (%) |
| 0 (control) | 50 | 0 | 0 | 0 | 0 |
| 4 | 50 | 17(34) | 2(4) | 0 | 7(14) |
| 8 | 50 | 7(14) | 14(28) | 6(12) | 3(6) |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive
This study reported that Cadmium sulfide (form unspecified) induced chromosomal aberrations in cultured human lymphocyes. - Executive summary:
Shiraishi et al. (1972) reported an increased frequency of chromosome aberrations in human lymphocytes exposed to cadmium sulphide in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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