Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 614-074-2 | CAS number: 675106-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity testing waived
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Value:
- mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
Testing the acute toxicity of a material such as this is extremely difficult. In accordance with annex xi section 1 acute oral toxicity testing is not scientifically necessary. Administering sufficiently large doses to produce an acute effect would physically damage the nose, throat and mouth of any animal. Study Basic toxicokinetics.002 used a dose of 4 g/kg and over 48 hours post dose only transient distress was seen. In study basic toxicokinetics 001 rats were fed up to 2.5% in diet over two years without evident toxicity. Again in accordance with annex xi section 1 acute inhalation toxicity testing is not scientifically necessary. A chronic inhalation study described at section 7.7 used a fibre test atmosphere of 28 mg/m3 without evident toxicity and another described at 7.5.2 exposed rats to concentrations close to 12 mg/m3 of milled fibre dust (with respirability greater than that of the fibres themselves) up to 86 weeks with minimal effect. Taken together with the chemically inert nature of the substance and the absence of absorption/ systemic distribution reported at section 7.1.1, this information makes low acute inhalation toxicity of the fibres predictable and new animal testing unjustifiable. In accordance with annex xi section 1 acute toxicity testing is not necessary. Low toxicity by oral and inhalation routes is shown elsewhere in this dossier together with a demonstration of a lack of absorption and systemic distribution following repeated oral intake. Taken together with the chemically inert nature of the substance makes acute dermal toxicity predictably insignificant and new animal testing unjustifiable. Overall there is no liklihood of acute toxic effects.
Justification for classification or non-classification
Testing the acute toxicity of a material such as this is extremely difficult. There are no valid results for these endpoints and classification as acutely toxic should not apply.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.