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EC number: 939-525-3 | CAS number: 1471313-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted similarly to OECD Guideline 401 with deviations: no data about purity and no certificate of analysis of test substance; no. of animals at two dose levels < 5; no details on environmental conditions, observation period: 7 days
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no data about purity and no certificate of analysis of test substance; no. of animals at two dose levels < 5; no details on environmental conditions, observation period: 7 days
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Remarks:
- before GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol; 6-(2,2,3-trimethylcyclopent-3-en-1-yl)hexan-3-ol
- EC Number:
- 939-525-3
- Cas Number:
- 1471313-03-7
- Molecular formula:
- C14H26O
- IUPAC Name:
- 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol; 6-(2,2,3-trimethylcyclopent-3-en-1-yl)hexan-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Sandalore
- Source: Proprietary Perfumes Ltd.
- Date received: 21 December 1976
- Physical state: Clear colourless liquid
- Specific gravity: 0.89
- pH: 4.0
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 weeks
- Housing: Animals were housed in individual cages.
- Fasting period before study: 4 h
- Diet: Commercial pelleted diet, ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME ADMINISTERED: 10 mL/kg bw
- Doses:
- 2, 5 and 10 mL/kg bw
- No. of animals per sex per dose:
- 5 mL/kg bw: 3/sex/dose
2 and 10 mL/kg bw: 1/sex/dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Survivors were weighed before killing for post-mortem examination.
- Necropsy of survivors performed: Yes, survivors were killed at the end of the one week observation period. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: equivalent to 8900 mg/kg bw; specific gravity: 0.89
- Mortality:
- - No mortality was observed.
- Clinical signs:
- other: - Mice dosed at 10 mL/kg bw were showing signs of stress within 30 minutes after treatment but recovered within one hour. - Mice dosed at 2 and 5 mL/kg bw appeared unaffected by the treatment.
- Gross pathology:
- - No macroscopic abnormalities were observed at study termination except pale intestines in the mice dosed at 10 mL/kg bw.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of the substance is higher than 2000 mg/kg bw in mice. Therefore it is not classified according to Directive 67/548/EEC and CLP Regulation (EC) N° 1272/2008.
- Executive summary:
In an acute oral toxicity study performed similarly to OECD Guideline 401, groups of mice (1 or 3/sex/dose) were given a single oral dose of the substance at 2, 5 and 10 mL/kg bw. Animals were then observed for mortality, clinical signs and bodyweights for 7 days and were all macroscopically necropsied after sacrifice.
No mortality and no abnormal clinical signs were observed. Animals dosed at 10 mL/kg bw were showing signs of stress within 30 minutes after treatment but recovered within one hour. The overall body weight gain of the treated animals was not affected by treatment with the test item except one female dosed at 5 mL/kg bw that lost a gram. No macroscopic abnormalities were observed at study termination except pale intestines in the mice dosed at 10 mL/kg bw. In this study, the combined oral LD50 was considered to be higher than 10 mL/kg bw (equivalent to 8900 mg/kg bw) in mice.
Under the test conditions, the oral LD50 is higher than 2000 mg/kg bw in mice. Therefore the substance is not classified according to Directive 67/548/EEC and CLP Regulation (EC) N° 1272 /2008.
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