Προηγούμενες/Αποτελέσματα
Προηγούμενες/Αποτελέσματα
Προηγούμενες/Αποτελέσματα
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid | 500-130-2 | 55818-57-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/05/2016 | 15/07/2016 | Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole | 500-181-0 | 68002-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminomethyl-3,5,5-trimethylcyclohexylamine | 500-101-4 | 38294-64-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers | 500-180-5 | 67989-52-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid | 500-090-6 | 36425-16-8 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral || Note: testing proposed with a structurally related substance (small vinyl ester) |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
4,4'-methylenebis[2,6-diethylaniline] | 237-185-4 | 13680-35-8 |
Genetic toxicity in vivo Long-term toxicity to fish |
26/03/2018 26/03/2018 |
11/05/2018 11/05/2018 |
Details | |
4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline] | 249-204-3 | 28768-32-3 |
Reproduction toxicity (two generation reproductive toxicity) Reproductive toxicity (developmental toxicity) Sub-chronic toxicity (90-day): dermal |
26/01/2011 26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 14/03/2011 |
Details | |
4,4'-methylenebis[N-sec-butylaniline] | 226-122-6 | 5285-60-9 | Bioaccumulation aquatic / sediment | 27/01/2020 | 12/03/2020 | Details | |
4,4'-methylenedi-2,6-xylenol | 226-378-9 | 5384-21-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 03/04/2023 | 22/05/2023 | Details | |
4,4'-methylenediphenyl diisocyanate | 202-966-0 | 101-68-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/11/2021 | 10/01/2022 | Details | |
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol | 701-072-2 | - | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no: 202-966-0) | 16/06/2022 | 01/08/2022 | Details | |
4,4'-Methylenediphenyl diisocyanate, oligomeric reaction products with 2,4'-diisocyanatodiphenylmethane | 500-297-1 | 109331-54-6 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 31/01/2023 | 17/03/2023 | Details | |
4,4'-Methylenediphenyl diisocyanate, oligomers | 500-040-3 | 25686-28-6 | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 16/06/2022 | 01/08/2022 | Details | |
4,4'-oxydi(benzenesulphonohydrazide) | 201-286-1 | 80-51-3 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/03/2014 21/03/2014 21/03/2014 |
05/05/2014 05/05/2014 05/05/2014 |
Details | |
4,4'-sulfonyldiphenol | 201-250-5 | 80-09-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
4,4'-sulphonyldiphenol | 201-250-5 | 80-09-1 | Long-term toxicity to fish | 16/06/2022 | 01/08/2022 | Details | |
4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane | 260-350-7 | 56706-10-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/03/2011 15/03/2011 |
29/04/2011 29/04/2011 |
Details | |
4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane | 260-350-7 | 56706-10-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
23/04/2018 23/04/2018 |
07/06/2018 07/06/2018 |
Details | |
4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane | 240-212-2 | 16068-37-4 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 03/08/2020 03/08/2020 |
Details | |
4,4`-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with methacrylic acid | 500-089-0 | 36425-15-7 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 |
Details | |
4,6-dichloro-N-(1,1,3,3-tetramethylbutyl)-1,3,5-triazin-2-amine | 276-309-1 | 72058-41-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
4,8-Dimethyl-2,5,7,10-tetraoxaundecane | 813-999-0 | 59039-15-5 | Long-term toxicity to fish | 30/06/2023 | 14/08/2023 | Details | |
4-((Triethoxysilyl)methyl) morpholine | 480-370-1 | 21743-27-1 |
Reproductive toxicity (developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day) |
27/11/2009 27/11/2009 27/11/2009 |
11/01/2010 11/01/2010 11/01/2010 |
Details | |
4-(1,1-dimethylethyl)cyclohexyl acrylate | 282-104-8 | 84100-23-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline | 233-215-5 | 10081-67-1 | Sub-chronic toxicity (90-day): oral | 18/02/2014 | 04/04/2014 | Details | |
4-(1-oxo-2-propenyl)-morpholine | 418-140-1 | 5117-12-4 | Genetic toxicity in vivo | 21/09/2020 | 05/11/2020 | Details | |
4-(4-isopropoxyphenylsulfonyl)phenol | 405-520-5 | 95235-30-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/08/2020 | 08/10/2020 | Details | |
4-[3-(1-naphthylamino)propyl]morpholine | 226-033-2 | 5235-82-5 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide – nano form | 220-509-3 | 2786-76-7 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with [3-hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide] (EC no. 229-440-3) | 03/10/2023 | 17/11/2023 | Details | |
4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
4-fluoro-1,3-dioxolan-2-one | 483-360-5 | 114435-02-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl | 218-760-9 | 2226-96-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl | 218-760-9 | 2226-96-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 |
Details | |
4-hydroxy-4-methylpentan-2-one | 204-626-7 | 123-42-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/09/2016 01/09/2016 |
17/10/2016 17/10/2016 |
Details | |
4-hydroxybenzophenone | 214-507-1 | 1137-42-4 | Genetic toxicity in vivo | 18/02/2021 | 05/04/2021 | Details | |
4-methylcyclohexanone | 209-665-3 | 589-92-4 |
6.1.2 Long-term toxicity to fish 7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity |
08/03/2024 08/03/2024 08/03/2024 |
22/04/2024 22/04/2024 22/04/2024 |
Details | |
4-methylmorpholine | 203-640-0 | 109-02-4 | Sub-chronic toxicity (90-day): oral | 25/11/2021 | 10/01/2022 | Details | |
4-methylmorpholine 4-oxide, monohydrate | 231-391-8 | 7529-22-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 02/04/2015 |
Details | |
4-methylpentan-2-one | 203-550-1 | 108-10-1 | Long-term toxicity to fish | 06/06/2023 | 21/07/2023 | Details | |
4-methylthiosemicarbazide | 229-563-2 | 6610-29-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4-morpholinecarbaldehyde | 224-518-3 | 4394-85-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
4-morpholinecarbaldehyde | 224-518-3 | 4394-85-8 | Sub-chronic toxicity (90-day): oral | 04/04/2014 | 19/05/2014 | Details | |
4-nitrotoluene-2-sulphonic acid | 204-445-3 | 121-03-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
4-oxovaleric acid | 204-649-2 | 123-76-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
4-phenylbutan-2-one | 219-847-4 | 2550-26-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a read-across substance having similar formula structure and its carbon chain consists of even number of carbons | 22/11/2017 | 08/01/2018 | Details | |
4-phenylbutenone | 204-555-1 | 122-57-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
4-tert-butylcyclohexyl acetate | 250-954-9 | 32210-23-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with cis-4-tert-butylcyclohexyl acetate |
24/02/2020 | 09/04/2020 | Details | |
4-tert-butylpyrocatechol | 202-653-9 | 98-29-3 |
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
4-tert-butylpyrocatechol | 202-653-9 | 98-29-3 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
29/04/2011 29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 14/06/2011 |
Details | |
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] | 601-409-2 | 116020-44-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |