Προηγούμενες/Αποτελέσματα
Προηγούμενες/Αποτελέσματα
| 1,1,1,3,3,3-hexamethyldisilazane | 213-668-5 | 999-97-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
| Methylphosphonic acid | 213-607-2 | 993-13-5 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| 4'-hydroxyacetophenone | 202-802-8 | 99-93-4 | Reproductive toxicity (pre-natal developmental toxicity) | 25/10/2017 | 11/12/2017 | Details | |
| 1-isopropyl-4-methylcyclohexane | 202-790-4 | 99-82-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| 1,3-diisopropylbenzene | 202-773-1 | 99-62-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| Reaction products of Fatty acids, C16-18 and C18-unsatd. and reaction mass of 1,3-alkanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-heteromonocycle-5,5-dimethanol | 484-360-8 | 98859-60-0 | Reproductive toxicity (pre-natal developmental toxicity) | 17/08/2012 | 01/10/2012 | Details | |
| 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid | 500-281-4 | 98362-33-5 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 |
Details | |
| 2-Oxetanone, 3-C14-16-alkyl 4-C15-17-alkylidene derivs. | 308-760-8 | 98246-87-8 | Long-term toxicity to fish | 22/09/2022 | 07/11/2022 | Details | |
| Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction | 308-482-7 | 98072-31-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
| Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction | 308-482-7 | 98072-31-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
01/08/2011 01/08/2011 |
15/09/2011 15/09/2011 |
Details | |
| Cyclohexyldimethylamine | 202-715-5 | 98-94-2 | Reproductive toxicity (pre-natal developmental toxicity) | 01/07/2021 | 16/08/2021 | Details | |
| 4-tert-butylpyrocatechol | 202-653-9 | 98-29-3 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
29/04/2011 29/04/2011 29/04/2011 |
14/06/2011 14/06/2011 14/06/2011 |
Details | |
| 4-tert-butylpyrocatechol | 202-653-9 | 98-29-3 |
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
| Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs. | 308-208-6 | 97925-95-6 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
| Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs. | 308-208-6 | 97925-95-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed on rabbits | 14/08/2014 | 28/09/2014 | Details | |
| 2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs | 307-276-4 | 97592-79-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
| Resin acids and Rosin acids, fumarated, esters with glycerol | 307-051-0 | 97489-11-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6) |
19/07/2013 19/07/2013 |
02/09/2013 02/09/2013 |
Details | |
| 1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromo-2-methylpropoxy)benzene] | 306-832-3 | 97416-84-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/07/2021 01/07/2021 |
16/08/2021 16/08/2021 |
Details | |
| Dodecene, branched | 306-479-5 | 97280-83-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene), branched (EC no. 500-004-7) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| bis(piperidinothiocarbonyl) hexasulphide | 213-537-2 | 971-15-3 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 16/02/2015 | 02/04/2015 | Details | |
| bis(piperidinothiocarbonyl) hexasulphide | 213-537-2 | 971-15-3 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2014 | 13/06/2014 | Details | |
| Ethylene dimethacrylate | 202-617-2 | 97-90-5 | Sub-chronic toxicity (90-day): oral | 03/10/2023 | 17/11/2023 | Details | |
| 5-sulphosalicylic acid | 202-555-6 | 97-05-2 | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
| Soybean oil, epoxidized, Me ester, reaction products with propylene glycol | 306-246-8 | 96690-51-6 | Genetic toxicity in vivo | 18/03/2021 | 03/05/2021 | Details | |
| Amines, C12-14-tert-alkyl, mixed sec-Bu and iso-Bu phosphates | 306-227-4 | 96690-34-5 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates (EC 279-632-6) || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
| 2,4-di-tert-butylphenol | 202-532-0 | 96-76-4 | Sub-chronic toxicity (90-day): oral | 16/05/2011 | 30/06/2011 | Details | |
| tetrahydro-2-methylfuran | 202-507-4 | 96-47-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| tetrahydro-2-methylfuran | 202-507-4 | 96-47-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
23/01/2015 23/01/2015 |
09/03/2015 09/03/2015 |
Details | |
| Imidazolidine-2-thione | 202-506-9 | 96-45-7 | Long-term toxicity to fish | 29/04/2011 | 14/06/2011 | Details | |
| methyl acrylate; methyl propenoate | 202-500-6 | 96-33-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
| Pentan-3-one | 202-490-3 | 96-22-0 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
| Fatty acids, C8-10, C12-18-alkyl esters | 306-082-7 | 95912-86-0 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/04/2022 01/04/2022 01/04/2022 |
16/05/2022 16/05/2022 16/05/2022 |
Details | |
| Reaction mass of 1-(1-Methyl-2-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)ethoxy)-propan-2-ol and 1-(2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yloxy)propoxy)-propan-2-ol and 2-(2-(1,7,7-trimethylbicyclo-[2.2.1]hept-2-yloxy]-propoxy)-propan-1-ol and 2-(1-Methyl-2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yloxy)ethoxy)-propan-1-ol | 470-680-5 | 958872-63-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-days): oral |
21/01/2011 21/01/2011 |
07/03/2011 07/03/2011 |
Details | |
| 3-hydroxy-1,1-dimethylbutyl 2-ethyl-2-methylheptaneperoxoate | 413-910-1 | 95718-78-8 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2012 17/04/2012 17/04/2012 |
01/06/2012 01/06/2012 01/06/2012 |
Details | |
| 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 213-485-0 | 957-68-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
10/08/2018 10/08/2018 10/08/2018 |
24/09/2018 24/09/2018 24/09/2018 |
Details | |
| Hydrocarbons, C4, 1,3-butadiene- and isobutene-free | 306-004-1 | 95465-89-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| 4-(4-isopropoxyphenylsulfonyl)phenol | 405-520-5 | 95235-30-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/08/2020 | 08/10/2020 | Details | |
| Rosin, fumarated, reaction products with formaldehyde | 305-795-0 | 95009-65-7 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
| Rosin, fumarated, reaction products with formaldehyde | 305-795-0 | 95009-65-7 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0). Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
| 1,2,4-trimethylbenzene | 202-436-9 | 95-63-6 | Reproductive toxicity (pre-natal developmental toxicity) | 03/10/2023 | 17/11/2023 | Details | |
| o-cresol | 202-423-8 | 95-48-7 | Long-term toxicity to fish||Note: testing proposed with p-cresol (EC no. 203-398-6) | 10/05/2022 | 27/06/2022 | Details | |
| o-xylene | 202-422-2 | 95-47-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with p-xylene (EC 203-396-5) | 22/04/2021 | 07/06/2021 | Details | |
| Benzotriazole | 202-394-1 | 95-14-7 | Reproductive toxicity (pre-natal developmental toxicity) | 22/10/2013 | 05/12/2013 | Details | |
| (1-hydroxycyclohexyl) (phenyl)methanone (hydroxycyclohexyl phenyl ketone) | 213-426-9 | 947-19-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
28/02/2011 28/02/2011 28/02/2011 |
14/04/2011 14/04/2011 14/04/2011 |
Details | |
| Hydroxycyclohexyl phenyl ketone | 213-426-9 | 947-19-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/09/2019 | 01/11/2019 | Details | |
| Resin acids and Rosin acids, maleated, esters with pentaerythritol | 305-516-2 | 94581-17-6 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7) Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6) |
19/07/2013 19/07/2013 |
02/09/2013 02/09/2013 |
Details | |
| Resin acids and Rosin acids, fumarated, esters with pentaerythritol | 305-514-1 | 94581-15-4 | Reproductive toxicity (pre-natal developmental toxicity) | 16/07/2012 | 30/08/2012 | Details | |
| Resin acids and Rosin acids, fumarated, esters with pentaerythritol | 305-514-1 | 94581-15-4 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7) Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7) Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6) Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6) |
19/07/2013 02/07/2013 02/07/2013 19/07/2013 19/07/2013 02/07/2013 |
02/09/2013 16/08/2013 16/08/2013 02/09/2013 02/09/2013 16/08/2013 |
Details | |
| Sodium N-(2-carboxyethyl)-N-(2-ethylhexyl)-β-alaninate | 305-318-6 | 94441-92-6 | Reproductive toxicity (pre-natal developmental toxicity) | 02/06/2014 | 17/07/2014 | Details | |
| Saccharomyces cerevisiae, lysate | 305-230-8 | 94350-12-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/09/2021 30/09/2021 |
15/11/2021 15/11/2021 |
Details | |
| Trimethyl-3-[(1-oxo-10-undecenyl)amino]propylammonium methyl sulphate | 304-990-8 | 94313-91-4 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl trimethyl-3-[(1-oxododecyl)amino]propylammonium sulphate EC 234-204-8 || Note: Testing proposal is based on concern identified by the registrant | 16/12/2020 | 01/02/2021 | Details | |
| Aluminum, benzoate C16-18-fatty acids complexes | 303-385-6 | 94166-87-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
| N-phenylmaleimide | 213-382-0 | 941-69-5 | Genetic toxicity in vivo | 29/04/2011 | 14/06/2011 | Details | |
| Dimethyl cyclohexane-1,4-dicarboxylate | 202-347-5 | 94-60-0 | Reproductive toxicity (pre-natal developmental toxicity) | 15/04/2014 | 30/05/2014 | Details | |
| Ethylene dibenzoate | 202-338-6 | 94-49-5 |
Developmental neurotoxicity Reproductive toxicity (pre-natal developmental toxicity |
21/05/2018 21/05/2018 |
05/07/2018 05/07/2018 |
Details | |
| Dibenzoyl peroxide | 202-327-6 | 94-36-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/12/2020 16/12/2020 16/12/2020 |
01/02/2021 01/02/2021 01/02/2021 |
Details | |
| Dibenzoyl peroxide | 202-327-6 | 94-36-0 | Reproductive toxicity (pre-natal developmental toxicity) | 16/06/2011 | 01/08/2011 | Details | |
| 2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) | 202-319-2 | 94-28-0 | Sub-chronic toxicity (90-day): oral | 26/01/2011 | 14/03/2011 | Details | |
| 2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) | 202-319-2 | 94-28-0 | Reproductive toxicity (pre-natal developmental toxicity) | 01/07/2021 | 16/08/2021 | Details | |
| 2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) | 202-319-2 | 94-28-0 | Reproductive toxicity (two-generation reproductive toxicity) | 18/09/2014 | 03/11/2014 | Details | |
| Vinyl 2-ethylhexanoate | 202-297-4 | 94-04-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/10/2022 | 12/12/2022 | Details | |
| Vinyl 2-ethylhexanoate | 202-297-4 | 94-04-2 | Reproductive toxicity (two-generation reproductive toxicity) | 14/10/2011 | 28/11/2011 | Details | |
| (octahydro-4,7-methano-1H-indenyl)methyl acrylate | 300-723-4 | 93962-84-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
| 3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile | 300-496-1 | 93940-97-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane | 300-344-4 | 93925-42-9 | Genetic toxicity in vivo | 21/01/2021 | 08/03/2021 | Details | |
| Gas oils, paraffinic | 300-227-8 | 93924-33-5 | Reproductive toxicity (two-generation reproductive toxicity) | 02/09/2011 | 17/10/2011 | Details | |
| Alkenes, C24-28 α- | 300-203-7 | 93924-11-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 25/06/2012 |
15/07/2011 15/07/2011 09/08/2012 |
Details | |
| Alkenes, C20-24 α- | 300-202-1 | 93924-10-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 25/06/2012 |
15/07/2011 15/07/2011 09/08/2012 |
Details | |
| Reaction mass of Alkenes C20-24 and Alkenes C24-28 | 931-746-3 | 93924-10-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
03/11/2011 03/11/2011 16/07/2012 |
19/12/2011 19/12/2011 30/08/2012 |
Details | |
| Reaction mass of (E)-3-methyl-5-phenylpent-2-enenitrile and (Z)-3-methyl-5-phenylpent-2-enenitrile | 299-682-2 | 93893-89-1 | Reproductive toxicity (pre-natal developmental toxicity) | 16/12/2020 | 01/02/2021 | Details | |
| tripotassium propylsilanetriolate | 299-135-8 | 93857-00-2 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with [trimethoxypropylsilane] (EC 213-926-7) Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with [trimethoxypropylsilane] (EC 213-926-7) |
16/03/2015 16/03/2015 |
30/04/2015 30/04/2015 |
Details | |
| Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) | 298-577-9 | 93819-94-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Alkenes, C15-18 | 297-797-2 | 93762-80-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2011 16/08/2011 25/06/2012 |
30/09/2011 30/09/2011 09/08/2012 |
Details | |
| Phosphorous acid, tri-C12-14-alkyl esters | 297-701-9 | 93686-48-7 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) |
16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 |
Details | |
| Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenated | 297-629-8 | 93685-81-5 | Reproductive toxicity (two-generation reproductive toxicity) | 25/06/2012 | 09/08/2012 | Details | |
| 2,2'-[hexane-1,6-diylbis(oxymethylene)]dioxirane | 618-939-5 | 933999-84-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/10/2017 | 11/12/2017 |
|
Details |
| Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane | 618-939-5 | 933999-84-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): dermal |
18/11/2014 18/11/2014 18/11/2014 |
02/01/2015 02/01/2015 02/01/2015 |
Details | |
| Ashes (residues), plant | 297-049-5 | 93333-79-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 |
Details | |
| Ashes (residues), plant | 297-049-5 | 93333-79-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2011 16/05/2011 16/05/2011 |
30/06/2011 30/06/2011 30/06/2011 |
Details | |
| 2-ethyl-4-methylimidazole | 213-234-5 | 931-36-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
| 1-(vinyloxy)octadecane | 213-208-3 | 930-02-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| Methyl benzoate | 202-259-7 | 93-58-3 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
| 2-(2-naphthyloxy)ethanol | 202-228-8 | 93-20-9 | Genetic toxicity in vivo | 16/05/2014 | 30/06/2014 | Details | |
| Renewable hydrocarbons (diesel type fraction) | 618-882-6 | 928771-01-1 | Reproductive toxicity (pre-natal developmental toxicity) | 01/09/2017 | 16/10/2017 | Details | |
| tert-butyl peroxypivalate | 213-147-2 | 927-07-1 | Reproductive toxicity (pre-natal developmental toxicity) | 21/03/2014 | 05/05/2014 | Details | |
| Dimethyl(propyl)amine | 213-139-9 | 926-63-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Ethyldimethylamine (EC 209-940-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Ethyldimethylamine (EC 209-940-8) |
18/02/2021 18/02/2021 |
05/04/2021 05/04/2021 |
Details | |
| 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar-heptyl ar',ar''-Me derivs. | 296-120-8 | 92257-31-3 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
| Rosin, fumarated, reaction products with glycerol and pentaerythritol | 296-047-1 | 92202-14-7 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7) Reproductive toxicity (two-generation reproductive toxicity) //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS 94581-15-4) Sub-chronic toxicity (90-day): oral //Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS RN 97489-11-7), Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS RN 94581-15-4), and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS RN 94581-17-6) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Resin acids and Rosin acids, fumarated, esters with glycerol (CAS 97489-11-7); Resin acids and Rosin acids, fumarated, esters with pentaerythritol (CAS 94581-15-4); and Rosin acids and resin acids, maleated, esters with pentaerythritol (CAS 94581-17-6) |
19/07/2013 19/07/2013 02/07/2013 19/07/2013 02/07/2013 |
02/09/2013 02/09/2013 16/08/2013 02/09/2013 16/08/2013 |
Details | |
| Rosin, fumarated, reaction products with glycerol and pentaerythritol | 296-047-1 | 92202-14-7 | Reproductive toxicity (pre-natal developmental toxicity) | 16/07/2012 | 30/08/2012 | Details | |
| Resin acids and Rosin acids, reaction products with formaldehyde, potassium salt | 295-855-1 | 92129-53-8 | Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), and Rosin, reaction products with formaldehyde (CAS RN 91081-53-7) | 02/07/2013 | 16/08/2013 | Details | |
| Fatty acids, tall-oil, compds. with N-[3-(dimethylamino)propyl]tall-oil amides | 295-714-4 | 92128-22-8 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
| Fatty acids, tall-oil, compds. with N-[3-(dimethylamino)propyl]tall-oil amides | 295-714-4 | 92128-22-8 | Reproductive toxicity (pre-natal developmental toxicity) | 28/02/2018 | 16/04/2018 | Details | |
| dihydro-3-(tripropenyl)furan-2,5-dione | 295-556-6 | 92077-08-2 | Reproductive toxicity (pre-natal developmental toxicity) | 30/09/2015 | 16/11/2015 | Details | |
| Residues (petroleum), thermal cracked vacuum | 295-518-9 | 92062-05-0 |
Genetic toxicity in vivo||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Asphalt (EC no. 232-490-9) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Asphalt (EC no. 232-490-9) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Asphalt (EC no. 232-490-9) |
04/12/2023 04/12/2023 04/12/2023 04/12/2023 |
18/01/2024 18/01/2024 18/01/2024 18/01/2024 |
Details | |
| Residues (petroleum), thermal cracked vacuum | 295-518-9 | 92062-05-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
| Gas oils (petroleum), hydrotreated light vacuum | 295-407-5 | 92045-24-4 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
| Hydrocarbons, C4, steam-cracker distillate | 295-405-4 | 92045-23-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1) Sub-chronic toxicity (90 day): inhalation||Note: testing proposed with Hydrocarbons, C4, 1,3-butadiene- and isobutene-free (EC no. 306-004-1) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| Biphenyl-4,4'-diol | 202-200-5 | 92-88-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
| Biphenyl-4,4'-diol | 202-200-5 | 92-88-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
| Biphenyl | 202-163-5 | 92-52-4 | Reproductive toxicity (pre-natal developmental toxicity) | 31/01/2018 | 19/03/2018 | Details | |
| Extracts (petroleum), deasphalted vacuum residue solvent | 295-332-8 | 91995-70-9 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Extracts (petroleum), residual oil solvent (EC no. 265-110-5) | 06/06/2023 | 21/07/2023 | Details | |
| Extracts (petroleum), deasphalted vacuum residue solvent | 295-332-8 | 91995-70-9 | Reproductive toxicity (two-generation reproductive toxicity) | 29/07/2011 | 12/09/2011 | Details | |
| Extracts (petroleum), deasphalted vacuum residue solvent | 295-332-8 | 91995-70-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): dermal |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| 3-aminopropyltriethoxysilane | 213-048-4 | 919-30-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
18/03/2021 18/03/2021 |
03/05/2021 03/05/2021 |
Details | |
| Sodium 1-hydroxyethanesulphonate | 213-037-4 | 918-04-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Cobalt, borate propionate complexes | 295-033-2 | 91782-61-5 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4)
|| Note: Testing proposal is based on concern identified by the registrant. Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
| Cobalt, borate 2-ethylhexanoate complexes | 295-032-7 | 91782-60-4 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4)
|| Note: Testing proposal is based on concern identified by the registrant Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant |
07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 |
Details | |
| Tar, wood | 294-436-0 | 91722-33-7 | Reproductive toxicity (pre-natal developmental toxicity) | 23/02/2022 | 12/04/2022 | Details | |
| Resin acids and Rosin acids, maleated, calcium salts | 294-402-5 | 91722-01-9 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0) Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
| 1,3-Propanediol, 2,2-bis(hydroxymethyl)-, allyl ether | 293-883-9 | 91648-24-7 | Bioaccumulation aquatic / sediment || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
| 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-C12-14 acyl derivs., hydroxides, inner salts | 293-878-1 | 91648-19-0 |
Long-term toxicity to fish || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) Sub-chronic toxicity (90-day): oral || Note: testing proposed with 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) |
18/06/2018 18/06/2018 18/06/2018 |
02/08/2018 02/08/2018 02/08/2018 |
Details | |
| Dialkyl-methyl-dihydro-heteropolycyle | 815-131-6 | 913171-06-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/03/2020 | 07/05/2020 | Details | |
| Rosin, reaction products with formaldehyde | 293-659-0 | 91081-53-7 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: testing proposed with Rosin (CAS RN 8050-09-7) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with _ Rosin (CAS RN 8050-09-7) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), Rosin, reaction products with formaldehyde (CAS RN 91081-53-7) |
19/07/2013 02/07/2013 02/07/2013 |
02/09/2013 16/08/2013 16/08/2013 |
Details | |
| Rosin, reaction products with formaldehyde | 293-659-0 | 91081-53-7 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
| Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction | 293-263-8 | 91053-01-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7) Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| Fatty acids, C16-18, reaction products with diethanolamine | 293-014-3 | 91032-08-5 | Reproductive toxicity (pre-natal developmental toxicity) | 16/03/2015 | 30/04/2015 | Details | |
| Fatty acids, C16-18, isononyl esters | 292-960-4 | 91031-57-1 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/06/2023 30/06/2023 30/06/2023 |
14/08/2023 14/08/2023 14/08/2023 |
Details | |
| Fatty acids, C16-18, barium salts | 292-883-6 | 91002-07-2 | Long-term toxicity to fish //Note: testing to be done with barium dichloride (CAS number 10361-37-2) | 04/04/2014 | 19/05/2014 | Details | |
| 6-phenyl-1,3,5-triazine-2,4-diamine | 202-095-6 | 91-76-9 | Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (pre-natal developmental toxicity) | 12/06/2013 | 29/07/2013 | Details | |
| Decahydronaphthalene | 202-046-9 | 91-17-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
| decahydronaphthalene | 202-046-9 | 91-17-8 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
| 3,5-diamino-4-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]benzoic acid sodium salt | 480-890-9 | 906532-68-1 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 18/11/2014 | 02/01/2015 | Details | |
| Amines, polyethylenepoly-, tetraethylenepentamine fraction | 292-587-7 | 90640-66-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with TETA (CAS 90640-67-8) and HEPA (68121-73-7) Reproductive toxicity (pre-natal developmental toxicity ) |
31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 |
Details | |
| Amines, polyethylenepoly-, tetraethylenepentamine fraction | 292-587-7 | 90640-66-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/11/2015 | 16/12/2015 | Details | |
| Amines, polyethylenepoly-, triethylenetetramine fraction | 292-588-2 | 90640-66-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/11/2017 22/11/2017 |
08/01/2018 08/01/2018 |
|
Details |
| Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched | 292-588-2 | 90640-66-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/09/2017 01/09/2017 |
16/10/2017 16/10/2017 |
|
Details |
| Amines, polyethylenepoly-, triethylenetetramine fraction,Triethylenetetramine linear, cyclic and branched | 292-588-2 | 90640-66-7 | Reproductive toxicity (two-generation reproductive toxicity) | 05/04/2011 | 20/05/2011 | Details | |
| Alkanes, C12-26-branched and linear | 292-454-3 | 90622-53-0 | Reproductive toxicity (two-generation reproductive toxicity) | 15/09/2011 | 31/10/2011 | Details | |
| Alkenes, C13-14, hydroformylation products, distn. residues | 292-429-7 | 90622-29-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6) | 02/11/2018 | 17/12/2018 | Details | |
| Alkenes, C13-14, hydroformylation products, distn. Residues | 292-429-7 | 90622-29-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
| Alkenes, C11-12, hydroformylation products, distn. residues | 292-427-6 | 90622-27-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 31/10/2011 |
Details | |
| Alkenes, C11-12, hydroformylation products, distn. Residues | 292-427-6 | 90622-27-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2018 | 16/04/2018 | Details | |
| 1,5-Pentanediamine, 2-methyl-, reaction products with 2-ethyl-1,4-butanediamine and glycidyl tolyl ether | 291-813-1 | 90480-76-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
| Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts | 291-454-0 | 90411-76-0 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
| 2,5-bis(1,1,3,3-tetramethylbutyl)hydroquinone | 212-990-3 | 903-19-5 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
| 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters | 290-754-9 | 90218-76-1 | Sub-chronic toxicity (90-day): oral | 29/07/2011 | 12/09/2011 | Details | |
| 2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated | 500-022-5 | 9014-85-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS number 126-86-3) || |
25/11/2019 | 09/01/2020 | Details | |
| 2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 | Long-term toxicity to fish | 22/09/2022 | 07/11/2022 | Details | |
| 2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Resin acids and Rosin acids, calcium salts | 232-694-8 | 9007-13-0 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
| Resin acids and Rosin acids, calcium salts | 232-694-8 | 9007-13-0 |
Reproductive toxicity (pre-natal developmental toxicity || Note: Testing proposed with Rosin CAS 8050-09-7 Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposed with Rosin CAS 8050-09-7 Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin CAS 8050-09-7, Rosin hydrogenated CAS 65997-06-0, and Rosin reaction products with formaldehyde CAS 91081-53-7 |
02/07/2013 02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 16/08/2013 |
Details | |
| Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- | 500-012-0 | 9004-77-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1). Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) | 500-004-7 | 9003-29-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
| 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene | 618-312-6 | 898566-17-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 |
Details | |
| Bis(4-methylbenzoyl)peroxide | 407-950-9 | 895-85-2 | 6.1.2 Long-term toxicity to fish||Note: testing proposed with p-toluic acid (EC no. 202-803-3) or with bis(4-methylbenzoyl) peroxide (EC no. 407-905-9) | 08/03/2024 | 22/04/2024 | Details | |
| 6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one | 403-830-5 | 89331-94-2 | Sub-chronic toxicity (90-day): oral | 26/03/2018 | 11/05/2018 | Details | |
| 6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one | 403-830-5 | 89331-94-2 | Bioaccumulation aquatic / sediment | 12/06/2015 | 27/07/2015 | Details | |
| 6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one | 403-830-5 | 89331-94-2 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
23/04/2018 23/04/2018 23/04/2018 |
07/06/2018 07/06/2018 07/06/2018 |
Details | |
| 6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one | 403-830-5 | 89331-94-2 | Sub-chronic toxicity (90-day): oral | 02/09/2013 | 18/10/2013 | Details | |
| pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate | 402-420-3 | 89157-03-9 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
| Thymol | 201-944-8 | 89-83-8 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
| Menthol | 201-939-0 | 89-78-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/09/2017 | 16/10/2017 | Details | |
| Reaction mass of trans-Cyclohexadecen-8-one, cis-Cyclohexadecen-8-one, trans-Cyclohexadecen-7-one, cis-Cyclohexadecen-7-one | 448-300-4 | 88642-03-9 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
| Phthalic acid | 201-873-2 | 88-99-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with phthalic anhydride (EC no. 201-607-5) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with phthalic anhydride (EC no. 201-607-5) |
21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 |
Details | |
| 2-tert-butylphenol | 201-807-2 | 88-18-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
| 3,3,5-trimethylcyclohexan-1-one | 212-855-9 | 873-94-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
| Vinylene carbonate | 212-825-5 | 872-36-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/05/2021 20/05/2021 20/05/2021 |
05/07/2021 05/07/2021 05/07/2021 |
Details | |
| Vinylene carbonate | 212-825-5 | 872-36-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/11/2021 | 10/01/2022 | Details | |
| Dec-1-ene | 212-819-2 | 872-05-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 25/06/2012 |
15/07/2011 15/07/2011 09/08/2012 |
Details | |
| Triethyl phosphonoacetate | 212-757-6 | 867-13-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with a read-across member of the ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
"Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“
" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Fatty acids, tall-oil, compds. with oleylamine | 288-315-1 | 85711-55-3 | Long-term toxicity to fish | 04/04/2014 | 19/05/2014 | Details | |
| Fatty acids, C14-18 and C16-18-unsatd., maleated | - | 85711-46-2 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
11/11/2016 11/11/2016 11/11/2016 |
03/01/2017 03/01/2017 03/01/2017 |
Details | |
| Alkenes, C10-14 | 288-213-7 | 85681-75-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/09/2011 15/09/2011 25/06/2012 |
31/10/2011 31/10/2011 09/08/2012 |
Details | |
| Alcohols, C13-15-branched and linear | 287-625-4 | 85566-16-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Isotridecan-1-ol (EC 248-469-2) | 16/12/2020 | 01/02/2021 | Details | |
| Alcohols, C13-15-branched and linear | 287-625-4 | 85566-16-1 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) |
31/01/2023 31/01/2023 |
17/03/2023 17/03/2023 |
Details | |
| Alkenes, C10-13 | 287-479-1 | 85535-87-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
| Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins) | 287-476-5 | 85535-84-8 | Reproductive toxicity (two-generation reproductive toxicity) | 29/07/2011 | 12/09/2011 | Details | |
| 2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt | 286-344-4 | 85209-91-2 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
| 2-Butenedioic acid (Z)-, ester with 1,2-propanediol, compd. with 2-(dibutylamino)ethanol | 286-304-6 | 85204-10-0 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 17/07/2014 |
Details | |
| Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-[(4-methyl-3-sulphonatophenyl)sulphonyl]phenyl]azo]naphthalene-2-sulphonate | 286-122-7 | 85187-33-3 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 18/02/2021 | 05/04/2021 | Details | |
| 2-ethylhexanoic acid, monoester with propane-1,2-diol | 285-503-5 | 85114-00-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
| Fatty acids, C16-18 and C18-unsatd., Et esters | 285-206-0 | 85049-36-1 | Long-term toxicity to fish | 01/07/2011 | 15/08/2011 | Details | |
| 1,3-diethyldiphenylurea | 201-645-2 | 85-98-3 | Sub-chronic toxicity (90-day): oral | 03/03/2014 | 17/04/2014 | Details | |
| Phthalic anhydride | 201-607-5 | 85-44-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
18/03/2021 18/03/2021 |
03/05/2021 03/05/2021 |
Details | |
| Phosphoric acid, mixed esters with Bu alc. and ethylene glycol | 284-716-0 | 84962-20-9 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1 |
20/05/2015 20/05/2015 |
06/07/2015 06/07/2015 |
Details | |
| 1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] | 284-366-9 | 84852-53-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/02/2020 | 09/04/2020 | Details | |
| C8-C26 branched and linear hydrocarbons - Distillates | 481-740-5 | 848301-67-7 | Bioaccumulation aquatic / sediment | 11/05/2010 | 25/06/2010 | Details | |
| Star anise, Illicium verum, ext. | 283-518-1 | 84650-59-9 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
| Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) and another read-across member from ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
| (Z)-4-[C11-13(branched)alkylamino]-4-oxo-2-butenoic acid | 701-116-0 | 84583-68-6 | Sub-chronic toxicity (90-day): oral || Note: The previous EC number for the substance is 283-219-6. | 22/06/2017 | 07/08/2017 | Details | |
| 2-Butenoic acid, 4-oxo-4-(tridecylamino)-, (Z)-, branched | 283-219-6 | 84583-68-6 | Sub-chronic toxicity (90-day): oral | 12/04/2017 | 29/05/2017 | Details | |
| Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate | 282-810-6 | 84434-11-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 |
Details | |
| 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates | 282-617-7 | 84281-74-3 | Genetic toxicity in vivo | 25/11/2021 | 10/01/2022 |
|
Details |
| 1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether | 282-199-6 | 84144-79-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 18/03/2021 | 03/05/2021 | Details | |
| 4-(1,1-dimethylethyl)cyclohexyl acrylate | 282-104-8 | 84100-23-2 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
| Formaldehyde, reaction products with ethylenediamine | 281-928-5 | 84066-92-2 | Genetic toxicity in vivo | 16/05/2014 | 30/06/2014 | Details | |
| 2-ethylanthraquinone | 201-535-4 | 84-51-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| Benzoic acid, 2-hydroxy-, mono-C>13-alkyl derivs., calcium salts (2:1) | 281-018-8 | 83846-43-9 | Sub-chronic toxicity (90-day): oral | 18/06/2018 | 02/08/2018 | Details | |
| n4,n4'-hexane-1,6-diylbis[n-butyl-6-chloro-n,n'-bis(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine] | 835-183-3 | 83420-16-0 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/09/2021 30/09/2021 30/09/2021 |
15/11/2021 15/11/2021 15/11/2021 |
Details | |
| Bis(2,4,4-trimethylpentyl)phosphinic acid | 280-445-7 | 83411-71-6 | Sub-chronic toxicity (90-day): oral | 18/03/2021 | 03/05/2021 | Details | |
| Bis(2,4,4-trimethylpentyl)phosphinic acid | 280-445-7 | 83411-71-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/04/2014 29/04/2014 |
13/06/2014 13/06/2014 |
Details | |
| Bis(trimethoxysilylpropyl)amine | 280-084-5 | 82985-35-1 |
Reproductive toxicity (pre-natal developmental toxicity Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 |
Details | |
| Cobalt oxalate | 212-409-3 | 814-89-1 |
Carcinogenicity
|| Note: testing proposed with Cobalt dichloride (EC 231-589-4)
|| Note: Testing proposal is based on concern identified by the registrant. Genetic toxicity in vivo
|| Note: testing proposed with Cobalt sulphate (EC 233-334-2)
|| Note: Testing proposal is based on concern identified by the registrant. |
21/09/2020 21/09/2020 |
05/11/2020 05/11/2020 |
Details | |
| Cobalt oxalate | 212-409-3 | 814-89-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
| bismuth citrate | 212-390-1 | 813-93-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
| 2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide | 686-241-8 | 81058-27-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 6,15-dihydroanthrazine-5,9,14,18-tetrone | 201-375-5 | 81-77-6 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |