Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 950-299-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Adequate read-across data are available on alkanes, C14 -17, chloro to predict the properties of di-, tri- and tetrachlorotetradecane. No deaths or other severe adverse affects were reported in a number of acute oral studies, in which rats were given single doses of C14-17 chlorinated paraffins (40 -52% chlorination; with or without 0.2-1% epoxy stabiliser). The oral LD50 is greater than 10 mL/kg bw. There are no acute inhalation or dermal exposure studies on di-, tri- and tetrachlorotetradecane available in laboratory animals. No acute human data is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2 )The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes
To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination.
For the above reasons the required endpoint is sufficiently covered by the testing on the read across substance Alkanes, C14-17, chloro EC number: 287-477-0 and the hazard adequately assessed. It is therefore considered that further testing on vertebrates is not required. - Reason / purpose for cross-reference:
- read-across source
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Remarks on result:
- other: No confidence intervals given
- Mortality:
- No deaths observed
- Clinical signs:
- other: Clinical signs of toxicity were not mentioned in respect of the C14-17 chlorinated paraffins, being confined "mainly" to rats which received a high dose (4 g/kg bw or above) of the C10-13 chlorinated paraffins. They included piloerection, muscular incoord
- Gross pathology:
- The general comment was that hepatocellular vacuolation and occassional necrotic foci were seen in the liver and cloudy swelling of some inner cortical cells was seen in the kidney. These effects were mainly seen in the animals treated with the C10-13 chlorinated parafins, which showed signs of toxicity, and were not mentioned specifically for the C14-17 chlorinated paraffin-treated rats.
- Other findings:
- - Other observations: occasional inflamation of the gastric mucosa was observed following administration of "some chlorinated paraffins" (not further specified in review).
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No deaths or other severe adverse effects were seen in rats given single unspecified doses of various C14-17 chlorinated paraffins (ranging from 51-60% chlorination) by stomach tube (from between 0.5 and 10 g/kg bw) and observed for 14 days. The acute oral LD50 was reported as greater than 4 g/kg bw.
- Executive summary:
No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.
No deaths or other severe adverse effects were seen in rats given single unspecified doses of various C14-17 chlorinated paraffins (ranging from 51-60% chlorination) by stomach tube (from between 0.5 and 10 g/kg bw) and observed for 14 days. The acute oral LD50 was reported as greater than 4 g/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2 )The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes
To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination.
For the above reasons the required endpoint is sufficiently covered by the testing on the read across substance Alkanes, C14-17, chloro EC number: 287-477-0 and the hazard adequately assessed. It is therefore considered that further testing on vertebrates is not required. - Reason / purpose for cross-reference:
- read-across source
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No confidence limits given
- Mortality:
- No deaths reported.
- Clinical signs:
- other: Restricted to incontinence during the first 48 hours, although numbers of animals affected and with which specific test material not reported.
- Gross pathology:
- No data
- Other findings:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No deaths or other severe adverse effects were seen in rats observed for 14 days following gavage administration of Meflex DC024 or Meflex DC029 (C14-17 chlorinated paraffins; 40 or 45% chlorination) as a single oral dose at 10 ml/kg bw . The oral LD50 is greater than 10 ml/kg bw.
- Executive summary:
No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.
The oral LD50 is greater than 10 ml/kg bw.
Referenceopen allclose all
No data is presented on which specific chlorinated paraffin the effects were attributed, the dose levels at which the effects occurred, or on whether the test material contains added stabilizer (0.2% epoxidized vegetable oil). It is not possible to delineate the results of the work on SCCPs and MCCPs
No data was available on the effects of the individual materials on individual animals
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The acute oral LD50 for di-, tri- and tetrachlorotetradecane in rats is greater than 2 g/kg bw. According to EU CLP regulation, under the conditions of these studies, di-, tri- and tetrachlorotetradecane would not be classified as acutely toxic by the oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.