Registration Dossier
Registration Dossier
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EC number: 946-682-1 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-04-02 to 2019-05-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- According to the test design, a phase separation via centrifugation was not necessary. This deviation was considered to have no impact on study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- yes
- Remarks:
- According to the test design, a phase separation via centrifugation was not necessary. This deviation was considered to have no impact on study.
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: June 07th - June 10th, 2016 & July 13th, 2016 / Date of signature: January 3rd 2017
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.055 µg/L
- Temp.:
- 20 °C
- pH:
- 7.2
- Details on results:
- The water solubility was determined for seven sampling intervals with two replicates each.
Mean: 1.055 μg/L
Deviation: 16% - Conclusions:
- The water solubility of test item was determined according to EU A6 and OECD 105 guidelines, using the flask method.
The solubility of the test item was determined at 20 +/- 0.5 °C to be 1.055 μg/L (pH 7.2). - Executive summary:
The water solubility of test item was determined according to EU A6 and OECD 105 guidelines, using the flask method.
The solubility of the test item was determined at 20 +/- 0.5 °C to be 1.055 μg/L (pH 7.2).
Reference
Description of key information
The solubility of the test item was determined at 20 +/- 0.5 °C to be 1.055 μg/L (pH 7.2).
Key value for chemical safety assessment
- Water solubility:
- 1.055 µg/L
- at the temperature of:
- 20 °C
Additional information
A fully reliable experimental study, conducted according to OECD 105/ EU A6 guideline is available.
It is considered as a key study, and the result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
