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Diss Factsheets
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EC number: 946-448-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Remarks:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read-across document
- Reason / purpose for cross-reference:
- read-across source
- Radiolabelling:
- no
- Key result
- Phase system:
- other: log Kp
- Type:
- other: log Kp
- Value:
- 3.5
- Remarks on result:
- other: C12 LAS
- Key result
- Phase system:
- other: log Kp
- Type:
- other: log Kp
- Value:
- 3.4
- Remarks on result:
- other: C11.6 LAS
- Adsorption and desorption constants:
- Kp (C12 LAS): 3210 L/kg (log Kp = 3.5)
Kp (commercial C11.6 LAS mixture): 2,500 L/kg (log Kp = 3.4) - Details on results (Batch equilibrium method):
- Sorption equilibrium was achieved rapidly, within 5-10 minutes. Desorption was less pronounced, but still reached rapid equilibration. The sludge-water partition coefficient Kp of 3210 L/kg volatile suspended solids is reported. Applying the same QSAR for the commercial C11.6 LAS mixture results in a value of log Kp = 3.4 (i.e., Kp = 2500 L/kg), consistent with Feijtel et al. 1999 (see section 3.3.1(b)). In the other experiments conducted in this study, only 2-8% was present as dissolved C12 LAS, with the remaining 92-98% adsorbed to the sludge. Despite this high degree of sorption, more than 99% of the LAS load was removed by biodegradation, showing that the adsorbed fraction as well as the soluble fraction of LAS is readily available for biodegradation.
- Conclusions:
- The log Kp for commercial LAS was 3.4.
- Executive summary:
The adsorption-desorption of LAS (read across) in activated sludge was determined in batch experiments. The Kp for commercial LAS was 2,500 L/kg, with a log Kp of 3.4.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see attached read across documentation for complete justification.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- Koc
- Value:
- 0.949 L/kg
- Remarks on result:
- other: Koc estimate from log Kow
- Type:
- log Koc
- Value:
- -0.023 L/kg
- Remarks on result:
- other: Koc estimate from log Kow
- Conclusions:
- The calculated Koc for MIPA was 0.9494.
Referenceopen allclose all
Description of key information
The adsorption-desorption of LAS (read across) in activated sludge was determined in batch experiments. The Kp for commercial LAS was 2,500 L/kg, corresponding to a log Kp of 3.4.
The calculated Koc for the second read across substance (MIPA) was 0.949 L/kg.
Key value for chemical safety assessment
- Koc at 20 °C:
- 2 500
Additional information
The adsorption-desorption of LAS (read across) in activated sludge was determined in batch experiments. The Kp for commercial LAS was 2,500 L/kg, corresponding to a log Kp of 3.4. Sorption equilibrium was achieved rapidly, within 5-10 minutes. Desorption was less pronounced, but still reached rapid equilibration. A sludge-water partition coefficient Kp of 3,210 L/kg volatile suspended solids is also reported for C12 LAS (log Kp = 3.5) based on the work of Feijtel et al. (1999). Those researchers found that only 2-8% of commercial LAS was present as dissolved C12 LAS, with the remaining 92-98% adsorbed to the sludge. Despite this high degree of sorption, more than 99% of the LAS load was removed by biodegradation, showing that the adsorbed fraction as well as the soluble fraction of LAS is readily available for biodegradation.
The EPISuite calculated Koc value for the second read across substance (MIPA) was 0.949 L/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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