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EC number: 944-892-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 April 2018 to 29 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 23 (Series on testing and assessment)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of butyl palmitate and butyl oleate and butyl (9Z,12Z)-octadeca-9,12-dienoate and 482-680-2
- EC Number:
- 944-892-8
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction mass of butyl palmitate and butyl oleate and butyl (9Z,12Z)-octadeca-9,12-dienoate and 482-680-2
- Test material form:
- liquid: viscous
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Twenty daphnids were exposed to butyl avocadate distillated at saturation concentration in test media. Saturation concentration solution was prepared in test medium and was divided in 4 replicates. A control (4 replicates) was performed at the same time with only test medium. the test was conducted in 125 mL glass flasks with 50 mL solution per flask. Test solutions were replaced by freshly prepared solutions after 24 hours. Five daphnids were introduced into each replicate. The number of immobilised daphnids was recorded after 24h and 48h in all replicates.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The test item solution was prepared by dissolution of 10.4 mg of butyl avocadate distillated in 500 mL of the test medium to obtain a nominal concentration higher than the saturation concnetration in test media. The solution was prepared in 1 L glass bottle and shaken during about 24 hours. Then this preparation was filtered through 0.2 µm filter (Whatman cellulose nitrate membrane filters). This solution was used for exposure and identified as saturation concentration. This preparation was repeated to renewall the exposure solution after 24h (10.1 mg of butyl avocadate distillated in 500 mL of the test medium).
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Culture conditions: Temperature at 20°C +/- 2°C, light/dark cycle 16/8 hours, freshwater (reconstituted from salts).
Age at the beginning of the test: Daphnids less than 24 hours old and produced from parthenogenically reproducing brood female population.
Origin: Culture at SGS France from Rouen Laboratory.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Remarks:
- reconstituted from salts
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- Value: 19.8 to 20.4
Criteria:20°C +/- 2°C - Dissolved oxygen:
- Value: 8.7
Criteria: > 3 - Details on test conditions:
- Test item preparation was repeated at 24h and alive daphnids were transferred in newly prepared solutions.
The test solutions at T0 and 24h (fresh solutions) were sampled (volume: 100 mL), extracted and quantified immediately according to the validated method.
The test was carried out at 20°C +/- 2°C in the dark (temperature was recorded automatically by Evisense Temperature Center).
The number of immobilised daphnids was recorded after 24h and 48h in all replicates.
After 24 and 48 hours, the 4 replicates of tested concentrations were respectively mixed. These test solutions were sampled (volume: 100 mL) and quantified immediately according to the validated method.
The pH and dissolved O2 values for each conditions were recorded at T0, T24 and T48h. - Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.47 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- See section "Any other information on results incl. tables" below
Any other information on results incl. tables
Data at 24h :
Test Condition | Daphnids immobilised per glass flask | |||||||
replicate A | Replicate B | Replicate C | Replicate D | Total of immobilised daphnids | Percentage of immobilisation | pH | Dissolved O2 (mg/L) | |
Control | 0 | 0 | 0 | 0 | 0 | 0% | 7.4 | 8.7 |
Saturation | 1 | 0 | 0 | 1 | 2 | 10% | 7.6 | 8.8 |
Data at 48h :
Test Condition | Daphnids immobilised per glass flask | |||||||
replicate A | Replicate B | Replicate C | Replicate D | Total of immobilised daphnids | Percentage of immobilisation | pH | Dissolved O2 (mg/L) | |
Control | 0 | 0 | 1 | 0 | 1 | 5% | 7.4 | 8.8 |
Saturation | 1 | 1 | 0 | 1 | 3 | 15% | 7.5 | 8.7 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Ecotoxicity test of Butyl avocadate distillated on Daphnia magna fulfils the requirements of OECD Guideline No. 202 to determine EC50-48h > 0.47 mg/L (saturation concentration)
- Executive summary:
Objective:
The scope of this study was, in compliance with the principles of Good Laboratory Practice (GLP), to determine the acute toxicity of butyl avocadate distillated on Daphnia magna in a 48 -hour semi-static test.
Method Summary:
Twenty daphnids were exposed to butyl avocadate distillated at saturation concentration in test medium. Four replicates were tested per concentration. Test solutions were replaced by freshly prepared solutions after 24 hours.
The number of immobilised daphnids was recorded 24h and 48h in all replicates.
Results:
Butyl avocadate distillated Based on measured concentration EC50 -48h > 0.47 mg/L Immobilisation at the saturation concentration in test media (0.47 mg/L) 15% Conclusion:
Ecotoxicity test of butyl avocadate distillated on Daphnia magna fulfils the requirements of OECD Guideline No. 202 to determine EC50 -48h > 0.47 mg/L (saturation concentration).
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