Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: 14C-IN-QEK31-011
Lot #: 1572460
Radiochemical Purity: 97.8%
Specific Activity: 69.12 μCi/mg - Radiolabelling:
- yes
Study design
- Analytical monitoring:
- yes
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.5 other: μg/mL
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.5 other: μg/mL
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.5 other: μg/mL
- Number of replicates:
- 02
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- The test item is hydrolytically stable, therefore no hydrolysis pathway is proposed.
Total recovery of test substance (in %)open allclose all
- % Recovery:
- >= 104.7 - <= 109.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: Mass Balance (% AR)
- % Recovery:
- >= 107.7 - <= 108.8
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: Mass Balance (% AR)
- % Recovery:
- >= 106.2 - <= 107.9
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: Mass Balance (% AR)
Dissipation DT50 of parent compound
- Key result
- Remarks on result:
- other: The hydrolytic half-life (t1/2) at 25°C is considered to be >1 year at pH 4, 7 and 9
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- This study demonstrated that the test item was hydrolytically stable at pH 4, 7 and 9.
Hydrolysis did not occur across all pH levels tested at 50°C. The hydrolytic half-life (t1/2) at 25°C is considered to be >1 year at pH 4, 7 and 9. - Executive summary:
The hydrolytic stability of the test item was investigated in sterile buffer solutions at pH 4, 7 and 9, which were incubated at 50 ± 0.5°C for 5 days, using 14C-test item
Solutions of 14C-test item were prepared in 0.01 M acetate buffer (pH 4), 0.01 M phosphate buffer (pH 7) and 0.01 M borate buffer (pH 9) at a nominal test concentration of 2.5 μg/mL, which was less than one-half of the solubility of the test item in each of these buffers.
At selected time intervals, samples were analyzed to determine the quantity of radioactivity present in each sample. Radioactivity was quantitatively recovered from each test solution. The material balance of radioactivity throughout the study for all test samples was within the range of 104.7 to 109.1% AR.
Test solutions were subjected to analysis by HPLC to investigate the nature of any hydrolysis products formed. The hydrolysis of the test item at 50 ± 0.5°C after 5 days of incubation was <3% in pH 4, 7 and 9 buffer solutions. Since the applied test item was recovered essentially unchanged after 5 days at 50°C, the test item was considered to be stable {t1/2 at 25°C >1 year} at pH 4, 7 and 9 and no further tests were performed.
Based on the results of this study, hydrolysis is not expected to be a route of degradation of the test item in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.