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EC number: 811-460-4 | CAS number: 53606-41-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-methoxy-5-nitrophenyl acetate
- Cas Number:
- 53606-41-0
- Molecular formula:
- C9H9NO5
- IUPAC Name:
- 2-methoxy-5-nitrophenyl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20°C (max. deviation of 2°C) with variation of 1°C at aach individual test
- pH:
- 7.7 (should be 7.8 with max. deviation of 0.2 for semistatic test)
- Dissolved oxygen:
- 8.0 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 51.5 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Remarks on result:
- other: 50.0-53.0 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 26.4 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Remarks on result:
- other: 20.5-32.3 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 7.3 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 4.9 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 73.9 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 73.9 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- The results of the verification test with K2Cr2O7, are the following:
24 hour – EC50 = 1.95 mg·L-1(95% confidence limit: 1.75 – 2.15 mg·L-1)
48 hour – EC50 = 0.86 mg·L-1(95% confidence limit: 0.70 – 1.02 mg·L-1)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The test substance, 2-methoxy-5-nitrophenyl acetate, was tested in acute immobilisation test on Daphnia magna.
The test was performed according to method C.2 – Daphnia sp. Acute Immobilisation Test, Council Regulation (EC) No. 440/2008, published in O.J.L 142, 2008.
The preliminary test was performed in range of the test substance nominal concentrations 1 – 100 mg·L-1. The analytical results showed, that the test substance 2-methoxy-5-nitrophenyl acetate was not stable in dilution water in the conditions of the test. Based on toxicity and instability of the test substance found in preliminary test, the definitive test was performed in appropriate concentration range and as semistatic.
The semistatic definitive test was performed in range of the test substance nominal concentrations 9 - 100 mg·L-1. The test solutions were renewed after 24 hours. The test substance concentrations was measured at the beginning, after 24 hours (before and after renewal) and at the end of the test.
There is stated in the guideline that, if evidence is available to demonstrate that the concentration of the test substance has been satisfactorily maintained within ± 20 percent of the nominal or measured initial concentration throughout the test, the results can be based on nominal or measured initial values.
Because concentrations of the test substance have not been satisfactorily maintained within ± 20 percent of the nominal or measured initial concentration throughout the test, time-weighted mean concentrations were used for all evaluations and results.
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