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EC number: - | CAS number: 1474044-66-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is not a skin sensitiser in guinea pigs based on a study performed with C8 alkane sulfonate.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 April - 10 May 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- no
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Study was already available
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Murphy Breeding Laboratories, Inc.
- Age at study initiation:no data
- Weight at study initiation: 225-325 g
- Housing: singly in wire mesh suspensioncages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days minimum
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr): 12 h/12 h
- Photoperiod (hrs dark / hrs light): 12 h/12 h - Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- induction: 25 %w/v of test substance
Challenge: 5 % w/v of test substance - Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- induction: 25 %w/v of test substance
Challenge: 5 % w/v of test substance - No. of animals per dose:
- 10 male/10 female
- Details on study design:
- RANGE FINDING TESTS:
Test substance applied at 100 %, 50 %, 25 %, 10 %, 5 %, 2.5 % or 1 % w/v in distilled water. 4 concentrations/ guinea pig. 0.3 mL/patch. Occluded conditions. Based on the results, a concentration of 25 %w/v was chosen for induction and 5 %w/v for primary challenge.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 6 hours
- Test groups: 0.3 mL of 25 %w/v solution
- Control group: none
- Site: upper left quadrant of backs
- Frequency of applications: weekly
- Duration: 6 hours under occlusive conditions
- Concentrations: 25 %w/v
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge:2 weeks after last induction
- Exposure period: 6 hours
- Test groups: 0.3 mL of 5 %w/v solution
- Control group: 0.3 mL of 5 %w/v solution
- Site: lower left quadrant of backs
- Concentrations: 5 %w/v solution
- Evaluation (hr after challenge): 24 & 48 h
OTHER: - Positive control substance(s):
- no
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 5 %w/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Mean severity of skin scores = 0.0
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5 %wv/v
- No. with + reactions:
- 1
- Total no. in group:
- 19
- Clinical observations:
- Mean severity of skin scores = 0.03
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 5 %w/v
- No. with + reactions:
- 3
- Total no. in group:
- 10
- Clinical observations:
- Mean severity of skin scores= 0.2
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5 %w/v
- No. with + reactions:
- 5
- Total no. in group:
- 19
- Clinical observations:
- Mean severity of skin scores = 0.1
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
Reference
One animal in the test group was found dead after the third induction. Necrospy showed lungs pale, liver pale, abdominal cavity filled witha red blood-like material and slight post mortem autolysis.
The incidence and severity of the responses in the test group was essentially comparable to that produced by the naive control group, indicating that sensitisation had not been induced.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a Buehler test performed using a method similar to OECD TG 406, C8 alkane sulfonate was found to be non-sensitising to the skin of guinea pigs.The incidence(1/19 and 5/19 positive reactions at 24 and 48 hours after challenge, compared to 0/10 and 3/10 for the negative controls)and severity of the responses in the test group was essentially comparable to that produced by the negative control group, indicating that sensitisation had not been induced. This result is read across to the substance as C8 alkane sulfonate is the main constituent and has the same structure as the other main constituent, C6 alkane sulfonate.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance is not sensitising, based on read across to data on the main constituent, which has the same structure as the other main constituent of the substance. Classification is not required.
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