Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-868-7 | CAS number: 54889-63-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
- OECD 423: LD50 > 2000 mg/kg bw
Acute toxicity via inhaltion
- OECD 423: LC50 > 5.2 mg/L
Acute dermal toxicity
- OECD 402: LD50 > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
oral:
In an acute oral toxicity study performed according to the Acute Toxic Class method according to OECD 423 (BASF SE, 2013, 10A0766/12X374), doses of 2000 mg/kg bw of the test item Cyclohexane, 1,4-bis(ethoxymethyl)- (undiluted) were administered to two test groups of three fasted Wistar rats each (2000 mg/kg bw in 6 females) by gavage in a sequential manner. No mortality occurred. The following test substance-related clinical observations were recorded: impaired general state (6/6), piloerection, (6/6), salivation (6/6), cowering position (3/6), dyspnoea (3/6), apathy (2/6), stagger (1/6), exophthalmos (1/6). There were no macroscopic pathological findings in the surviving animals sacrificed at the end of the observation period. The mean body weight of the surviving animals increased within the normal range throughout the study period, with the exception of one female (first test group), which showed stagnation of body weight during the second post-exposure week. The acute oral LD50 was calculated to be > 2000 mg/kg bw.
inhaltion:
To determine the acute inhalation toxicity (single 4-hour exposure, nose only) of 1,4-bis(ethoxy-methyl)-Cyclohexane as a liquid aerosol, a study was performed in male and female Wistar rats according to OECD-Guideline method 403, as well as EC and EPA
guidelines. The actual measured concentration was 5.207 mg/L (analytical concentration, limit test). Cascade impactor measurements resulted in particle size distributions with mass median aerodynamic diameters (MMADs) of 2.3 and 2.2 μm, which are well within the respirable range.
No mortality occurred at the tested concentration. Clinical signs of toxicity comprised of red encrusted nose, abdominal respiration indicating local irritation effect. Moreover, piloerection and substance contaminated fur. The effects were observed after exposure until the study day 1. No clinical signs and findings were observed from study day 2 onwards. The mean body weights of the animals decreased on the first post exposure observation day but increased thereafter. No gross pathological abnormalities were detected during the necropsy in the animals at the termination of the study. Under the current study conditions, the LC50 value was > 5.2 mg/L (calculated based on analytical concentration) in male and female Wistar rats after 4 hour inhalation exposure to liquid aerosol of 1,4-bis(ethoxymethyl)-Cyclohexane 97%.
dermal:
In an acute dermal toxicity study (Limit Test), young adult Wistar rats (5 males and 5 females) were dermally exposed to a single dose of 2000 mg/kg bw of the undiluted test item 1,4-bis(ethoxymethyl)-Cyclohexane 97%. The clipped application site (dorsal and dorso-lateral parts of the trunk, comprising at least 10% of the total body weight surface) was covered by semi-occlusive dressing during the 24-hour exposure period. The animals were observed for 14 days. No mortality occurred. Neither signs of systemic toxicity nor local skin effects were observed. The body weight of the animals increased within the normal range throughout the study period. No macroscopic pathologic abnormalities were noted in all animals examined at the end of the study. Accordingly, the acute dermal median lethal dose (LD50) was determined to be LD50, dermal, rat > 2000 mg/kg bw
Justification for classification or non-classification
The present data on acute oral toxicity do not fulfill the criteria laid down in regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.