Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Feb - 18 Mar 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202, part 2
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: To obtain fresh stock solution for the test, the test substance was weighed out to a precision of 0.1 mg and dissolved in and made up to volume (3 ml) with acetone. Defined amounts of stock solution - or dilutions of it - were pipetted proportionally into the filled jars. The final amount of acetone did not exceed 0.1 mL/L test water. Stock solution and acetone were stirred vigorously with a glass rod. For all concentrations 3 liters of test solution were prepared freshly three times a week (renewal of test solution). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Waterflea
- Strain: Daphnia magna STRAUS
- Source: The daphnids used in this test were bred in the animal maintenance room of the Oekobiologie of Hoechst Schering AgrEvo GmbH, Umweltforschung, (Environmental Sciences, Ecobiology).
- Age at study initiation: < 24 h
- Method of breeding: They were cultured in beakers (19x13 cm, approximate dimensions of internal height and diameter), containing initially 20
adult animals in 2 litre test water. Every ten days the daphnids were transferred into fresh water resulting in the initial biological loading. The Daphnia cultures were maintained at 20 ± 2°Celsius and a photoperiod of 16 hours light, 8 hours dark. All cultures were fed with unicellular green algae (Scenedesmus subspicatus CHODAT, strain 86.81 SAG) twice a week.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 231.1 - 248.9 mg CaCO3/L H2O
- Test temperature:
- 19.6 - 19.9 °C
- pH:
- 7.8 -7.9
- Dissolved oxygen:
- 8.9 – 9.3 mg/L in fresh solutions and 7.3 – 8.8 mg/L in old solutions
- Salinity:
- -
- Nominal and measured concentrations:
- Nominal test concentrations of 0 (control), 0 (0.1 mL acetone /L), 0.32, 0.56, 1.0, 1.8 and 3.2 mg/L test item
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 600 mL glass beakers containing 400 mL test water at an approximate depth of 78 – 83 mm
- Renewal rate of test solution: test medium renewed on study days 3, 5, 7, 10, 12, 14, 17, 19 and 21
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The dilution water was well aerated artificial mineral medium (M4) water modified according to (Elendt 1990).
- Intervals of water quality measurement: The dissolved oxygen, pH, conductivity and temperature were measured throughout the study. In
addition, freshly prepared testing water was analysed for total hardness, total alkalinity and nitrite content.
OTHER TEST CONDITIONS
- Photoperiod: The light-dark cycle was 16L/8D
- Light intensity: illuminated by wide spectrum fluorescent lights
EFFECT PARAMETERS MEASURED: Effects on adult survival and reproductive capacity, i.e. numbers of dead and alive offspring were
investigated on study days 3, 5, 7, 10, 12, 14, 17, 19 and 21.
VEHICLE CONTROL PERFORMED: yes - Reference substance (positive control):
- not specified
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- and offspring survival
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Reference
Biological results: There was no parental mortality in the control and any of the test item groups up to and
including 1800 μ/L. Significant mortality was observed at 3200 μg/L from Day 14 onwards. The 21d-EC50 was
therefore above the highest concentration of 3200 μg/L. First young were observed in the control and all testing
groups on Day 10. Throughout the study the number of alive young was significantly reduced at concentrations
> 560 μg/L test item. This effect was primarily due to reduced offspring number towards the end of the exposure
period.
Conclusion:
After 21-day exposure of daphnids to AE F107892 technical the NOEC for reproductive capacity and
offspring survival was considered to be 320 μg/L test item. The LOEC was 560 μg/L test item due to a doserelated
reduction in live young. The NOEC for parental mortality was 1800 μg/L due to increased (20%)
mortality at 3200 μg/L.
Description of key information
NOEC (21 d) = 0.32 mg/L with Daphnia magna (nominal, OECD 202 part II, reproduction)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.32 mg/L
Additional information
One key study on the parent substanc on the long-term toxicity of the substance to aquatic invertebrates is available. The key study was conducted according to OECD guideline 202, part II (1994). The test design was semi-static with five test concentrations ranging from 0.32 - 3.2 mg/L. The test solutions were prepared using acetone as vehicle. A NOEC (21 d) of 0.32 mg/L (nominal) was determined based on reproduction and offspring survival.
The supporting test on two different metabolites of the test item are available. The studies were conducted according to OECD guideline 211 under semi-static conditions with five test concentrations ranging from 0.32 - 3.2 mg/L. For one metabolite a NOEC (21 d) of 3.2 mg/L (nominal) based on reproduction was determined (2004). In the test on the chronic toxicity of the other metabolite a NOEC (21 d) of 32 mg/L (nominal) based on reproduction was recorded (2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.