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Diss Factsheets
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EC number: 466-490-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experiment start date - 07 July 2006; Experiment completion date - 09 August 2006; Study completion date - 24 January 2007.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identity: FAT 40827/A
Batch: T2 5572 BOP 01/06
Purity: determined in this study
Appearance: black sticky powder
Expiration date: 28.02.2011
Storage: at room temperature - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Standard Solutions
31.74 mg of FAT 40827/A was dissolved in 100 ml of water to prepare a stock solution of 317.4 µg/ml FAT 40827/A. Calculated volumes of this stock solution were diluted with water to obtain several standard solutions. Six of these solutions in the range from 6.348 µg/ml to 126.96 µg/ml FAT 40827/A were used to calibrate the HPLC-system.
During and at the end of the test the stability and accuracy of the calibration solution was confirmed by preparing and analysing new calibration solutions.
Sample Preparation
Before and after incubation, 10 µl aliquots of the test solutions at each pH value were analysed without dilution by measuring the UV signal of FAT 40827/A after HPLC separation of the injected sample solution - Buffers:
- Buffer pH 4, Biphthalate: Baker Art No. 5657
Buffer pH 7, Phosphate: Baker Art No. 5656
Buffer pH 9, Borate: Baker Art No. 7145 - Estimation method (if used):
- HPLC
- Details on test conditions:
- Glassware: All glassware, which must be inert in the pH range applied, was rinsed with sterile buffer. The hydrolysis was carried out in flasks, which were stoppered or sealed with an inert material. The test vessels were labelled with the following information: RCC study number and the additional information necessary to assure unmistakable identification.
Water Baths: Thermostatically controlled water baths: Julabo SW22 from Julabo
Balance: Mettier XP205DR
The test item was dissolved in an aqueous solution at a specific pH-value (pH 4.0, pH 7.0 and pH 9.0) and was incubated at a specific temperature with a maximum deviation of ± 0.5 °C and then kept constant within ± 0.1 °C. - Duration:
- 48 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 173.8 - <= 174.9 µg/L
- Duration:
- 58 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 184.1 - <= 185.6 µg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 99.5 - <= 106.1 µg/L
- Number of replicates:
- Two samples were determined for each pH value at different temperature.
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- Injected samples were quantified by peak area with reference to the calibration curve. The latter was obtained by correlation of the peak area of the analytical standards with their corresponding concentration. The correlation was performed using a least squares fit of a linear function. Therefore, the rate constant k is the slope of a plot of In ct versus t.
- Preliminary study:
- Test item was found to be stable at pH 7.0 and 50 °C. Therefore no further testing was performed at this pH-value.
Test item was not stable at pH 4.0 and at pH 9.0, further testing was performed at 50 °C, 60 °C and 70 °C in the buffered test solution at pH 4.0 and at
pH 9.0. - Test performance:
- The retention time of test item was at about 25.6 minutes under the HPLC-conditions.
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.003 h-1
- DT50:
- 206 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: The hydrolysis rate constant was not reported.
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.001 h-1
- DT50:
- 867 h
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Test item at pH 4.0 has a half-life time of 206 hours (9 days) at 25 °C, its half-life time is longer than one year at 25 °C and pH 7.0, and at pH 9.0 has a half-life time of 867 hours (36 days) at 25 °C.
- Executive summary:
The test was performed according to OECD Guideline for Testing of Chemicals No. 111 (2004) and EEC Directive 92/69, Section C.7 (1992) to evaluate the hydrolysis of test item as a function of pH. The test item was dissolved in aqueous buffer solution, and the temperature and pH were checked at pH 4, 7 and 9, respectively. The decrease of the concentration with time was determined by HPLC. The rate constant and the half-life period were calculated using the slope of the line (the logarithms of the concentration against time). The test results showed that the test substance at pH 4 has a half-life period of 206 hours (9 days) at 25 ℃, at pH 7 is stable with a half-life of more than one year at 25 ℃, and at pH 9 has a half-life period of 867 hours (36 days) at 25 ℃.
Reference
pH |
Temperature (°C) |
Reaction rate constant K (1/hours) |
Reaction rate constant K (1/s) |
Half-life time (hours) |
4.0 |
25 |
3.37×10-3 |
9.36×10-7 |
206 |
50 |
2.53×10-2 |
7.02×10-6 |
27 |
|
60 |
4.91×10-2 |
1.36×10-5 |
14 |
|
70 |
1.01×10-1 |
2.82×10-5 |
7 |
|
9.0 |
25 |
7.99×10-4 |
2.22×10-7 |
867 |
50 |
1.94×10-2 |
5.39×10-6 |
36 |
|
60 |
5.54×10-2 |
1.54×10-5 |
13 |
|
70 |
1.75×10-1 |
4.86×10-5 |
4 |
Description of key information
The test substance at pH 4 has a half-life period of 206 hours (9 days) at 25 ℃, at pH 7 is stable with a half-life of more than one year at 25 ℃, and at pH 9 has a half-life period of 867 hours (36 days) at 25 ℃.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The test was performed according to OECD Guideline for Testing of Chemicals No. 111 (2004) and EEC Directive 92/69, Section C.7 (1992) to evaluate the hydrolysis of test item as a function of pH. The test item was dissolved in aqueous buffer solution, and the temperature and pH were checked at pH 4, 7 and 9, respectively. The decrease of the concentration with time was determined by HPLC. The rate constant and the half-life period were calculated using the slope of the line (the logarithms of the concentration against time). The test results showed that the test substance at pH 4 has a half-life period of 206 hours (9 days) at 25℃, at pH 7 is stable with a half-life of more than one year at 25 ℃, and at pH 9 has a half-life period of 867 hours (36 days) at 25 ℃.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.