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EC number: 279-903-9 | CAS number: 82136-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion:
- Skin corrosive, Cat. 1B [based on results of a reliable study equivalent or similar to OECD Guideline 404 for the substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol].
- Results are as expected, given that the substance is a strong base (pH=12); as the available information indicates that the substance needs to be classified as skin corrosion Category 1B, there would actually have been no need to conduct a study.
Eye irritation:
- Serious eye damaging, Cat. 1 [based on the classification of the substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol as skin corrosive (sub-category 1B; H314)].
- The available experimental data of the study equivalent or similar to OECD Guideline 405 for 2-[[3-(dimethylamino)propyl]methylamino]ethanol would not be sufficient to classify the substance, but this is not required as the substance is classified as skin corrosive (sub-category 1B; H314); such a substance is automatically considered to be severely damaging to the eye and is classified but not labelled for serious eye damage in addition to skin corrosion.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 August 1980 (started); 30 September 1980 (reported)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study report provides basic data, but some details missing including type of coverage, duration of treatment, individual animal data and scoring system
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- study was conducted before implementation of GLP
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- weight at study initiation: 2.82 kg (mean)
- Type of coverage:
- not specified
- Preparation of test site:
- other: abraded skin (3 animals), intact skin (3 animals)
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 2.0 mL/animal
- Duration of treatment / exposure:
- 4 hours (not documented)
- Observation period:
- 30 days
- Number of animals:
- 6 total (3 male with intact skin, 3 male with abraded skin)
- Irritation parameter:
- other: overall corrosion
- Basis:
- mean
- Reversibility:
- other: reversible within 30 days
- Remarks on result:
- other: severe corrosion in all animals (with abraded and intact skin)
- Irritation parameter:
- other: overall erythema
- Basis:
- mean
- Reversibility:
- other: reversible within 30 days
- Remarks on result:
- other: severe erythema in all animals (with abraded and intact skin)
- Irritant / corrosive response data:
- scores (including the reversibility of the effects observed) for individual animals: not available
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- corrosive to rabbit skin (6 of 6 test animals)
- Executive summary:
In a primary dermal irritation study (equivalent or similar to OECD guideline 404, prior to introduction of GLP), 6 male New Zealand White rabbits - half with shaved, the other half with abraded skin - were dermally exposed to 0.2 mL of the undiluted test material 2-[[3-(dimethylamino)propyl]methylamino]ethanol (most likely for 4 hours under an occlusive bandage).
Animals were observed post dosing for erythema, edema and corrosion.
The undiluted test substance caused severe erythema and severe corrosivity in all animals, but the effects observed were fully reversible within the observation period of 30 days in all treated animals.
Although data on individual animals are missing and no information about the scoring system is available, the study is considered sufficient for classification and hazard identification on the basis of the unambiguous test results: in this study, severe corrosivity occured in 6 of 6 test animals.
The available information indicates that the substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol, being a strong base (pH=12), needs to be classified as Skin Corr. 1B [using the EU Globally Harmonised System (GHS)].
Reference
Table: Irritant/corrosive response data for each male rabbit
Erythema | Edema | Corrosion | |
Animal #1 (intact skin) | severe (reversible within 30 days) | - | severe (reversible within 30 days) |
Animal #2 (intact skin) | |||
Animal #3 (intact skin) | |||
Animal #4 (abraded skin) | severe (reversible within 30 days) | - | severe (reversible within 30 days) |
Animal #5 (abraded skin) | |||
Animal #6 (abraded skin) |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation
Based on the results of a reliable study equivalent or similar to OECD Guideline 404, the substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol, being a strong base (pH=12), meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 1B; H314.
Eye irritation
The substance 2-[[3-(dimethylamino)propyl]methylamino]ethanol is classified as skin corrosion (sub-category 1B; H314), leading to classification as serious eye damage (category 1; H318).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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