2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 09, 2018 - June 11, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

- Composition of test material: Sodium-2-ethylhexyliminomonopropionate and Sodium-2-ethylhexyliminodipropionate
- Analytical purity: >=98%
- Purity test date: 13 December 2017
- Lot/batch No.: WI6K21X06-FD2
- Expiration date of the lot/batch: 05 December 2018
- Appearance: White paste
- Storage: At room temperature

Key result

Remarks on result:

not determinable

Preliminary test

Starting at 200°C, the weight of the sample decreased significantly. At 237°C, the sample weight had decreased by 25%. After the experiment, black residue was observed on the lid of the sample container and a black residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

Main study

An endothermic peak was observed between 25°C and 175°C. Based on the weight loss observed during the preliminary test, the endothermic effect was due to evaporation of evaporation of impurities including residual water. An endothermic peak was observed starting at 175°C. The endothermic effect was due to reaction and/or decomposition of the test item. After the experiment, an off-white residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item. 

Conclusions:

The melting temperature of the test item was tested by DSC. Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 175°C (> 448K). Melting of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no melting temperature.

Executive summary:

The melting point of the test item was investigated in a GLP-compliant study performed in accordance with EC A.1 method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 175°C (> 448K). Melting of the test item was not observed below the temperature at which reaction and/or decomposition started.  Based on this, the test item has no melting temperature.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2012-01-20

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Determination has been run according to standardized method but without GLP compliance.

Qualifier:

according to guideline

Guideline:

other: ASTM E 537 – 07

Deviations:

no

GLP compliance:

no

Type of method:

other: differential scanning calorimetry

Remarks on result:

other: No melting point was detected in the interval -30-300°C. The sample is a paste at room temperature.

Conclusions:

No melting point was detected in the interval -30-300°C. The sample is a paste at room temperature.

Executive summary:

No melting point was detected in the interval -30-300°C. The sample is a paste at room temperature.

Description of key information

The melting point of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was investigated in a GLP-compliant study performed in accordance with EC A.1 method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 175°C (> 448K). Melting of the test item was not observed below the temperature at which reaction and/or decomposition started.  Based on this, the test item has no melting temperature.

Additional information

The melting point of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was investigated in a GLP-compliant study performed in accordance with standard methods, without deviations (Volic, 2018). The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.

The endpoint study summary for 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) is linked to study record(s) on the substance itself but also to study record(s) on an analogue substance, a.k.a. Sodium 3-[(2-carboxyethyl)(2-ethylhexyl)amino]propanoate (CAS RN 94441-92-6 / EC 305-318-6). The latter is used as source substance to fill datagaps on 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) for particular endpoints pertaining to environmental fate, aquatic toxicity and human health toxicity. Several physico-chemical data are thus reported for the source substance (e.g.physical state, melting point, vapour pressure, surface tension, water solubility and n-octanol/water partition coefficient – identified as “supporting studies”) to support the read-across approach (cf. read-across justification document attached in "13 Assessment reports").