Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-130-2 | CAS number: 68003-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Ammonium N-methyl-N-(1-oxododecyl)glycinate (CAS 68003-46-3) is a substance containing 290 g/L of the main constituent (Ammonium lauroyl sarcosinate) and 70% of water serving as additive. Furthermore, the substance is a salt characterized by low vapour pressure (5.10E-05 Pa, 25 °C, MPBVP v1.43), indicating that it is not volatile and that evaporation to air and subsequent transport through the atmosphere to other environmental compartments is not likely.
Since there is only limited experimental data available for the environmental fate of the substance, QSAR calculations were performed to estimate the dissociation constant (pKa), log Koc and log Kow values of the substance.
The calculated pKa of the substance is 3.3 ± 0.4 (QSAR, ACD I-Lab 2.0), indicating that the anionic form will predominate at environmentally relevant conditions of pH 4 to 9, which is expected to remain in solution. The estimated log Koc (ChemProp v6.5, Franco, Fu & Trapp) is 2.99 at pH 4 and 1.99 at pH 7 and 9, indicating a low potential for adsorption to particles present in soil and sediment in neutral to basic environments and a low to moderate potential for adsorption in more acidic environments. Thus, the substance is expected to be mobile in surface waters at environmentally relevant pH values of around 7.
Ammonium N-methyl-N-(1-oxododecyl)glycinate has a log D (used for ionisable substances instead of log Kow) of 3.28 at pH 4, 0.61 at pH 7 and -0.30 at pH 9 (SPARC v4.6) , indicating low lipophilicity at the environmentally relevant pH of 7 and 9. Thus, according to REACh regulation (EC) No 1907/2006 the substance has a low potential for bioaccumulation at the environmentally relevant pH of 7 and 9 as the log D is ≤ 3. Furthermore, the estimated BCF values also indicate that the potential for bioaccumulation is low. The estimated BCF values range from 3.16 to 150.7 L/kg wet-wt and are thus well below the threshold value of 2000 L/kg for bioaccumulative substances, as laid down by the REACH regulation (EC) No 1907/2006, section 1 of Annex XIII.
Based on experimental results from a standard biodegradation study, the substance is readily biodegradable (98.2% 28 d, OECD 301 A). Consequently, abiotic degradation via hydrolysis is not a relevant degradation pathway. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological sewage treatment plants (STPs) (ECHA, 2016). Hence, release into the environment is expected to be low due to ready biodegradability. Moreover, the substance will not persist in surface waters and bioavailability to aquatic organisms can therefore be expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.