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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Three studies have been conducted on the source chemical n-butyl acrylate and are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
1. Relative Rates of hydrolysis of Butyl Acrylate Isomers by Mammalian Esterases:
Result: n-Butyl acrylate is rapidly hydrolized at rates between 54-79 micorgrams/min/mg protein after 2 minutes to 43-72 micrograms/min/mg protein.
2. In vivo toxicokinetics in rats via oral gavage
Result: n-Butyl acrylate is rapidly absorbed and metabolized. The acrylate moiety is primarily metabolized to CO2. n-Butyl acrylate is hydrolyzed to acrylic acid and butanol.
3. In vivo toxicokinetics in rats via iv.
Results: n-Butyl acrylate is rapidly absorbed and metabolized. The acrylate moiety is primarily metabolized to CO2. n-Butyl acrylate is hydrolyzed to acrylic acid and butanol. The compound and metabolites were cleared very rapidly and elimination decreased to almost negligible rates after 2 hours.
Key value for chemical safety assessment
Additional information
The source chemical n-butyl acrylate is absorbed and the major portion is hydrolyzed to acrylic acid, which is further metabolized to compounds available for oxidative metabolism. The target chemical 2-methybutyl acrylate is expected to follow the same pathway with the exception that 2- methylbutanol would be formed rather than n-butanol.
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