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EC number: 248-670-5 | CAS number: 27816-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2 -methoxyethyl 2 -cyanoacrylate is not classified for skin irritation/corrosion as indicated by available information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The analogous material ß-methoxy-iso-propyl cyanoacrylate (MPCA) was examined for its acute dermal irriation properties according to OECD TG 404.
Eye irritation
The irritation potential of 2 -methoxyethyl 2 -cyanoacrylate to eyes and mucous membranes was evaluated in the HET-CAM (Hen's Egg Test – Chorioallantoic Membrane) by analysing specific effects to the membrane and/or vessels of the CAM of 9 day incubated chicken eggs. The HET-CAM was given preference as polymerization of 2 -methoxyethyl 2 -cyanoacrylate results in a turbid material that might interfere with opacity measurements in BCOP or ICE studies.
2 -Methoxyethyl 2 -cyanoacrylate was tested undiluted. Since the test item started to harden within 30 seconds on the CAM and became turbid, effects were evaluated using the endpoint method (EPM), though exposure period was prolonged to 5 minutes to have the hardening process completed. Coagulation or lysis were not observed after exposure of the test item to the CAM, but slight to moderate haemorrhaging effects were visible. However, in three of six eggs lifting of the cured polymer film resulted in mechanical damage of vessels. Considering all results, the highest summed up score was 8 for haemorrhage. Since the end point method was performed with an extended exposure period with mechanical damage occuring in some of the CAM after removal of the hardend material, and considering that no lytic and coagulating effects were observed, it is reasonable to assume that some of the haemorrhage was due to the mechanical stress linked to the hardening of the material and the subsequent lifting from the CAM. Therefore the summed up score appears to overestimate the irritative potential of 2 -methoxyethyl 2 -cyanoacrylate, hence, 2 -methoxyethyl 2 -cyanoacrylate is assumed to be rather slightly irritating.
Justification for classification or non-classification
Skin irritation
The mean values for erythema and oedema recorded 24, 48 and 72 hours after treatment with the analogous material ß-methoxy-iso-propyl cyanoacrylate did not equal or exceed the EU limit values (DSD/CLP) considered to indicate a significant inflammatory response to treatment.
The structural similarity between MPCA and 2-methoxyethyl 2-cyanoacrylates is significant with MPCA having a methyl group in vicinity of the methoxy group which is not found in 2-methoxyethyl 2-cyanoacrylate. This additional methyl group is considered to be chemically inert and is not expected to contribute to the substance's irritative potential. Hence, 2 -methoxyethyl 2 -cyanoacrylate is not classified for skin irritation/corrosion in analogy to MPCA.
Eye irritation
Since only haemorrhage was observed in the HET-CAM study which seems to be in part caused by mechanical damage when lifting the polymerized material from the CAM, the classification as moderately irritating based on the score found in the study is rather overestimating the irritative potential of 2 -methoxyethyl 2 -cyanoacrylate. Therefore, 2 -methoxyethyl 2 -cyanoacrylate is only considered to be slightly irritating without requirement of classification and labeling according to DSD and CLP, respectively.
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