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EC number: 242-768-1 | CAS number: 19035-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2020-02-17 to 2020-02-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 18.6 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 28 mg/L
- Incubation duration:
- >= 48 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.25 - <= 6.37
- Conclusions:
- The mean water solubility of the test item was determined to be 18.6 ± 1.5 mg/L at 20 °C and a pH value around 6.3.
- Executive summary:
The water solubility was determined according to OECD Guideline No. 105 using the flask method with analysis by HPLC with MS/MS-detection. Six aliquots of the test item, were weighed into separate flasks. Two flasks were stirred for 24 h, 48 h and 72 h, respectively. The difference between the results obtained after the last two incubation days was 11 %. The acceptance criterium was therefore fulfilled and the study is valid. For calculation of the overall mean the measured concentrations of the last two incubation days were used. The first incubation period was not considered, because the difference between the first and last incubation period exceeded the 15 % criterion. The mean water solubility of the test item was determined to be 18.6 ± 1.5 mg/L at 20 °C and a pH value around 6.3.
Reference
Sample No. |
1 |
2 |
3 |
4 |
5 |
6 |
Weighed amount of test item [mg] |
7.15 |
6.86 |
6.44 |
6.75 |
6.90 |
6.88 |
Volume of water [mL] |
250 |
250 |
250 |
250 |
250 |
250 |
Loading rate [mg/L] |
28.60 |
27.44 |
25.76 |
27.00 |
27.60 |
27.52 |
Agitation time at 30°C [hours] |
29.5 |
29.5 |
53.5 |
53.5 |
77.5 |
77.5 |
Equilibration time at 20°C [hours] |
24 |
24 |
24 |
24 |
24 |
24 |
pH value of test item solution |
6.32 |
6.27 |
6.34 |
6.25 |
6.32 |
6.37 |
Shaking time [Hours] |
Measured concentration of test item in sample [mg/L] |
Sample Preparation Factor |
Determined concentration of test item in sample [mg/L] |
Water solubility mean value [mg/L] |
Overall mean ± Std. Dev. [mg/L] |
29.5 |
0.758 |
20 |
15.2 |
15.9 |
- |
29.5 |
0.828 |
20 |
16.6 |
||
53.5 |
0.852 |
20 |
17.0 |
17.6 |
18.6 ± 1.5 |
53.5 |
0.904 |
20 |
18.1 |
||
77.5 |
1.03 |
20 |
20.7 |
19.6 |
|
77.5 |
0.930 |
20 |
18.6 |
Description of key information
The mean water solubility of the test item was determined to be 18.6 ± 1.5 mg/L at 20 °C and a pH value around 6.3.
Key value for chemical safety assessment
- Water solubility:
- 18.6 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to OECD Guideline No. 105 using the flask method with analysis by HPLC with MS/MS-detection. Six aliquots of the test item, were weighed into separate flasks. Two flasks were stirred for 24 h, 48 h and 72 h, respectively. The difference between the results obtained after the last two incubation days was 11 %. The acceptance criterium was therefore fulfilled and the study is valid. For calculation of the overall mean the measured concentrations of the last two incubation days were used. The first incubation period was not considered, because the difference between the first and last incubation period exceeded the 15 % criterion. The mean water solubility of the test item was determined to be 18.6 ± 1.5 mg/L at 20 °C and a pH value around 6.3.
The water solubility study from 2013 was disregarded due to significant methodological deficiencies. It is assumed that the reported slight turbidity of the solution corresponds to undissolved test item which lead to an overestimation of the concentration of dissolved test item.
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