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EC number: 239-473-5 | CAS number: 15454-75-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
Based on the modelled conditions, the reproductive NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
Link to relevant study records
- Endpoint:
- reproductive toxicity, other
- Remarks:
- Not specified
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- A read-across justification report (RAAF) will be added to Section 13 as soon as possible.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6. May/July 2006
- Deviations:
- not specified
- Principles of method if other than guideline:
- This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
The outcome of the QSAR model is “Known precedent reproductive and developmental toxic potential”, if the chemical has a potential to cause toxicity. The corresponding category is displayed in the report generated for the obtained prediction.
The other prediction results are “Not known precedent reproductive and developmental toxic potential” if the toxic potential of the input chemical is not known, and “Not covered by current version of the decision tree” if the identified structural features are not objects of the tree. - GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
- Species:
- other: QSAR; species not specified
- Dose descriptor:
- other: Developmental toxicity potential
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential.
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- Dose descriptor:
- other: Reproductive toxicity potential
- Generation:
- other: Not specified
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Not known reproductive and developmental toxic potential
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- Reproductive effects observed:
- not specified
- Conclusions:
- Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
- Executive summary:
The potential of the test material to cause reproductive or developmental toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
- Endpoint:
- reproductive toxicity, other
- Remarks:
- Not specified
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The following prediction was performed using the OECD QSAR Toolbox. A category was formed based on the current endpoint (DART scheme). The prediction was further refined from a large database of metadata based on relevant subcategories.
- Justification for type of information:
- A read-across justification report (RAAF) will be added to Section 13 as soon as possible.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6, May/July 2008
- GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
- Species:
- rabbit
- Strain:
- not specified
- Dose descriptor:
- NOEL
- Effect level:
- 368 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Based on the modelled conditions
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the average value from the 5 nearest neighbours compared by prediction descriptors.
- Critical effects observed:
- not specified
- Dose descriptor:
- NOEL
- Generation:
- other: Not specified
- Effect level:
- 368 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Based on the modelled conditions
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the average value from the 5 nearest neighbours compared by prediction descriptors.
- Critical effects observed:
- not specified
- Reproductive effects observed:
- not specified
- Lowest effective dose / conc.:
- 368 mg/kg bw/day
- Treatment related:
- not specified
- Conclusions:
- Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
- Executive summary:
The developmental toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the DART scheme category, and the results were refined using relevant subcategories.
Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
The target chemical falls within the applicability domain of the prediction.
Referenceopen allclose all
Toxicity of the target chemical (Not known precedent reproductive and developmental toxic potential) is predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The current prediction has no applicability domain.
The prediction was based on dataset comprised from the following descriptors: NOEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression: Result: In Domain
Substances used for the prediction should be:
Not known precedent reproductive and developmental toxic potential 'Strict' (DART scheme)
<AND> Bioavailable (Lipinski Rule Oasis)
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The potential of the test material to cause reproductive or developmental toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
The reproductive toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the DART scheme category, and the results were refined using relevant subcategories.
Based on the modelled conditions, the reproductive NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
The target chemical falls within the applicability domain of the prediction.
Effects on developmental toxicity
Description of key information
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- See read-across justification in Section 13.
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- REACH Guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
The outcome of the QSAR model is “Known precedent reproductive and developmental toxic potential”, if the chemical has a potential to cause toxicity. The corresponding category is displayed in the report generated for the obtained prediction.
The other prediction results are “Not known precedent reproductive and developmental toxic potential” if the toxic potential of the input chemical is not known, and “Not covered by current version of the decision tree” if the identified structural features are not objects of the tree. - GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
- Limit test:
- no
- Species:
- other: QSAR; species not specified
- Dose descriptor:
- other: Developmental toxicity potential
- Based on:
- not specified
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential.
- Remarks on result:
- not measured/tested
- Dose descriptor:
- other:
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential
- Remarks on result:
- not measured/tested
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
- Executive summary:
The potential of the test material to cause reproductive or developmental toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The following prediction was performed using the OECD QSAR Toolbox. A category was formed based on the current endpoint (DART scheme). The prediction was further refined from a large database of metadata based on relevant subcategories.
- Justification for type of information:
- See Read-Across Justification in Section 13.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6, May/July 2008
- GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Dose descriptor:
- NOEL
- Effect level:
- 368 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: Based on the modelled conditions
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the average value from the 5 nearest neighbours compared by prediction descriptors.
- Abnormalities:
- not specified
- Dose descriptor:
- NOEL
- Effect level:
- 368 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Based on the modelled conditions
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the average value from the 5 nearest neighbours compared by prediction descriptors.
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Lowest effective dose / conc.:
- 368 mg/kg bw/day
- Treatment related:
- not specified
- Conclusions:
- Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
- Executive summary:
The developmental toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the DART scheme category, and the results were refined using relevant subcategories.
Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
The target chemical falls within the applicability domain of the prediction.
Referenceopen allclose all
Toxicity of the target chemical (Not known precedent reproductive and developmental toxic potential) is predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The current prediction has no applicability domain.
The prediction was based on dataset comprised from the following descriptors: NOEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
Substances used for the prediction should be:
Not known precedent reproductive and developmental toxic potential 'Strict' (DART scheme)
<AND> Bioavailable (Lipinski Rule Oasis)
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The potential of the test material to cause reproductive or developmental toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
The developmental toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the DART scheme category, and the results were refined using relevant subcategories.
Based on the modelled conditions, the developmental NOEL of the test material in the rabbit was determined to be ca. 370 mg/kg bw/day.
The target chemical falls within the applicability domain of the prediction.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008 (CLP), the substance does not require classification with respect to reproductive or developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.