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EC number: 226-552-4 | CAS number: 5423-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 7.5
- St. dev.:
- 0.71
- Sampling time:
- 29 d
- Remarks on result:
- other: Average of 2 test bottles
- Details on results:
- - Theoretical CO2 production: The TOC concentration of the 1 g/L Guanidine phosphate (1:1) solution was determined to be 77.95 mg/L. The ThCO2 of guanidine phosphate (1:1) was calculated to be 0.29 mg CO2/mg.
- Biodegradation: The relative biodegradation values calculated from the measurements performed during the test period revealed no significant biodegradation of guanidine phosphate (1:1). In the toxicity control more than 25% biodegradation occurred within 14 days (33%, based on ThCO2). Therefore, the test substance was assumed not to inhibit microbial activity.
- Acceptability of the test:
The positive control substance was biodegraded by at least 60% (81% was observed) within 14 days.
The difference of duplicate values for %-degradation of the test substance was always less than 20%.
The total CO2 release in the blank at the end of the test did not exceed 40 mg/L (51 mg CO2per 2 litres of medium, corresponding to 25 mg CO2/L).
The Inorganic Carbon content (IC) of the test substance (suspension) in the mineral medium at the beginning of the test was less than 5% of the Total Carbon content (TC). Since the test medium was prepared in tap-water purified by reverse osmosis (Milli-RO water, carbon levels < 500 ppb), IC was less than 5% of TC (mainly coming from the test substance, 14 mg TOC/L). - Results with reference substance:
- - Functioning of the test system was checked by testing the reference substance sodium acetate, which showed a normal biodegradation curve. Biodegradation of sodium acetate at 14 days was 81%. The ThCO2 of sodium acetate was calculated to be 1.07 mg CO2/mg.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Guanidine phosphate (1:1) was not readily biodegradable under the conditions of the modified Sturm test. Therefore, the target substance bisguanidinium phosphate is also considered to be not readily biodegradable.
- Executive summary:
The readily biodegradation of guanidine phosphate (1:1) under the conditions of the carbon dioxide (CO2) evolution test (modified Sturm test) was investigated according to OECD guideline 301 B and GLP principles. A single test concentration of 14 mg TOC/L was tested during 28 days. Based on the obtained results, guanidine phosphate (1:1) was not readily biodegradable. The study is considered to be reliable without restrictions. Therefore, the target substance bisguanidinium phosphate is also considered to be not readily biodegradable.
Reference
Description of key information
Read Across: OECD 301B, GLP, CO2 evolution test, not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The readily biodegradation of guanidine phosphate under the conditions of the carbon dioxide (CO2) evolution test (modified Sturm test) was investigated according to OECD guideline 301B and GLP principles. A single test concentration of 14 mg TOC/L was tested during 28 days. Based on the obtained results, guanidine phosphate was not readily biodegradable. The study is considered to be reliable without restrictions. Therefore, the target substance bisguanidinium phosphate is also considered to be not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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