Registration Dossier
Registration Dossier
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EC number: 223-531-1 | CAS number: 3943-97-3
Endpoint summary
Administrative data
Description of key information
No data is available regarding skin/respiratory sensitisation of Methyl p-hydroxycinnamate (4-HCAME).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No experimental data is available regarding the skin sensitisation of Methyl p-hydroxycinnamate . The Toolbox profiler Protein binding by OASIS v1.3 gives an alert for skin sensitisation. An analogous substance Methyl cinnamate CAS 103-26-4 is classified H317 based on data reported in registration dossiers public on ECHA website.
Acting in a precautionary manner and based on alert provided by Toolbox profiler and the classification provided for the analogous substance Methyl cinnamate CAS 103-26-4 in the registration dossier public on ECHA website, the classification H317 (Skin sensitisation cat.1) is proposed for Methyl p-hydroxycinnamate (4-HCAME) according to the CLP Regulation (EC n. 1272/2008).
The public ECHA database contains data that are proprietary and cannot be used without the formal consent of the owner. In the present document, some of them have been used for precautionary purposes and for the benefit of the human health and the environment. Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the (eco) toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data is available regarding respiratory sensitisation of Methyl p-hydroxycinnamate (4-HCAME). Even though classified H317 (Skin sensitisation cat.1) this substance has no specific alert to trigger respiratory sensitisation concern and no classification is proposed according to the CLP regulation (EC n. 1272/2008). Moreover Methyl p-hydroxycinnamate is a transported isolated intermediate, it is used under strictly controlled conditions. The exposure for worker to Methyl p-hydroxycinnamate is minimized and there is no exposure for general population.
Justification for classification or non-classification
No experimental data is available regarding the sensitisation (skin or respiratory) of Methyl p-hydroxycinnamate . The Toolbox profiler Protein binding by OASIS v1.3 gives an alert for skin sensitization. Acting in a precautionary manner and based on alert provided by Toolbox profiler and the classification provided for the analogous substance Methyl cinnamate CAS 103-26-4 in the registration dossier public on ECHA website, the classification H317 (Skin sensitisation cat.1) is proposed for Methyl p-hydroxycinnamate (4-HCAME) according to the CLP Regulation (EC n. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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