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EC number: 219-144-2 | CAS number: 2372-45-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
As sodium butanolate is a highly unstable substance and hydrolysis can already be expected at air humidity, in vitro genotoxicity testing is not feasible.
Therefore, data from the hydrolysis products NaOH and n-Butanol are used to assess the potential for genetic toxicity of sodium butanolat in vitro.
The in vitro genetic toxicity tests with NaOH, CAS 1310-73-2, indicated no evidence of mutagenic activity. According to the REACH Regulation, further mutagenicity studies shall be considered in case of a positive result (column 2, Annexes VII, VIII). Therefore, further testing for mutagenicity is not relevant for NaOH. In vivo genetic toxicity tests with NaOH, CAS 1310-73-2 indicated no evidence for a mutagenic activity. Futhermore NaOH is not expected to be systemically available in the body under normal handling and use conditions (EU RAR, 2007; section 4.1.2.6.3, page 72). Therefore, additional testing is considered unnecessary.
Under the experimental conditions reported the test item n-butanol did not induce gene mutations at the HPRT locus in V79 cells.
n-Butanol did not induce chromosomal aberrations in an in vitro mammalian cell micronucleus test with V79 cells.
In none of the treatments of an Ames test, the maximum revertant factor exceeded a value of 1.5, indicating that the test substance n-butanol is not mutagenic in the Ames test under the tested conditions.
n-Butanol does not have any chromosome-damaging (clastogenic) effect, and there were no indications of any impairment of chromosome distribution in the course of mitosis in a micronucleus assay in vivo.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Existing data of the hydrolysis products of sodium butanolat (NaOH and n-Butanol) do not demonstrate any genotoxic or mutagenic properties.
Since hydrolysis of sodium butanolat occures immediately at air humidity, the properties of the hydolysis products can be used to derive its genetic toxicity potential. Therefore, sodium butanolate is considered not to be genotoxic and mutagenic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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