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EC number: 211-322-8 | CAS number: 638-16-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation (OECD 406, GPMT): not classified (no positive reactions were observed), read across of structurally similar substance
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The read-across hypothesis is based on structural similarity of target and source substance. Based on the available data, including physico-chemical properties and metabolism, the read-across strategy is additionally supported by a quite similar toxicological profile of source and target substance.
The respective data are summarised in the attached read across justification document.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source substance: 1,3,5-triazine-2,4,6-trithione, trisodium salt (CAS 17766-26-6)
Target substance: 1,3,5-triazine-2,4,6-trithione (= trithiocyanuric acid; CAS 638-16-4)
Further information can be found in the attached read-across justification.
3. ANALOGUE APPROACH JUSTIFICATION
The substances are structurally similar and are expected to show similar properties. Further information can be found in the attached read-across justification.
4. DATA MATRIX
Please refer to the data matrix included in the attached read-across justification document. - Reason / purpose for cross-reference:
- read-across source
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- induction: 0.1 and 1%; challenge: 75 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no dermal responses
- Remarks on result:
- other: based on read-across of source chemical
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- induction: 0.1 and 1%; challenge: 75 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no dermal responses
- Remarks on result:
- other: based on read-across of source chemical
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- induction: 0%; challenge: 75 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no dermal responses
- Remarks on result:
- other: based on read-across of source chemical
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- induction: 0%; challenge: 75 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no dermal responses
- Remarks on result:
- other: based on read-across of source chemical
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on structural similarities of the target and source substances as presented above and in more detail in the justification for read across, it can be concluded that the available data from the source substance TMT are also valid for the target substance TMT H3.
The available data on skin sensitisation do not meet the criteria for classification according to CLP Regulation (EC) No. 1272/2008, and are therefore conclusive but not sufficient for classification.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation study with source substance:
TMT was examined for its skin sensitisation potential in a Guinea Pig Maximisation test (GPMT) which was conducted under GLP according to OECD Guideline 406 adopted in 1981.
A pilot study was performed to evaluate irritating effects after intradermal and topical application. Concentrations of 0.1%, 1%, 3% and 5% of TMT 55 each in water and in a 1:1 mixture (v/v) FCA/water were used in the primary irritation screen. The highest concentration that did not produce ulceration and/or necrosis was determined to be 0.1% in water and 1% in a 1:1 mixture (v/v) FCA/water. Moreover concentrations of 9.5%, 19%, 38% and 75% in water were selected to determine the topical dermal irritation threshold concentration of TMT 55. No signs of irritation were evident for any of these concentrations after a 24 h exposure period.
Therefore, in the main study 20 Crl:(HA)BR VAF/Plus guinea pigs received an intradermal application of 0.1% test material in water and 1% test material in a 1:1 mixture (v/v) FCA/water for induction at day 0 of the experimental period. A control group with 20 animals were treated with water and adjuvance only. On day 7 occlusive patches with 75% of the test substance were applied on the same site of the test animals for 48 h for topical induction, the control group were treated with water only. On day 21 test and control animals were challenged with 75% test material by occluded patch for 24 h on the right flank. 24 h and 48 h after removing the patches, no dermal reactions were recorded. Thus it is concluded, that based on the results of this GPMT test TMT 55 is not skin sensitising.
As laid down in the read across justification, this negative result on skin sensitisation can be transferred to the target substance Taicros TMT.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation of Taicros TMT do not meet the criteria for classification according to CLP Regulation (EC) No. 1272/2008, and are therefore conclusive but not sufficient for classification
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